Method for regio-, chemo- and stereoselective deuterium labeling of sugars based on ruthenium-catalyzed C-H bond activation

被引：43

作者：

Fujiwara, Yuta ^{[1
]}

Iwata, Hiroki ^{[1
]}

Sawama, Yoshinari ^{[1
]}

Monguchi, Yasunari ^{[1
]}

Sajiki, Hironao ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Organ Chem Lab, Gifu 5011196, Japan

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 27期

基金：

日本学术振兴会;

关键词：

D EXCHANGE-REACTION; EFFICIENT H/D EXCHANGE; RANEY-NICKEL; SELECTIVE DEUTERATION; REGIOSELECTIVE DEUTERATION; HETEROGENEOUS PALLADIUM; AROMATIC-COMPOUNDS; MIXED CATALYST; N-ALKANE; METABOLISM;

D O I：

10.1039/c0cc01197e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and facile deuterium labeling of sugars has been achieved in a completely regio-, chemo- and stereoselective manner using the Ru/C-H(2)-D(2)O combination via C-H bond activation assisted by the coordination of Ru to the oxygen atom of the sugar-hydroxyl groups.

引用

页码：4977 / 4979

页数：3

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