Recent Advancements in Nanoparticle-Based Optical Biosensors for Circulating Cancer Biomarkers

被引：26

作者：

Amri, Chaima ^{[1
]}

Shukla, Arvind Kumar ^{[2
]}

Lee, Jin-Ho ^{[1
,2
]}

机构：

[1] Pusan Natl Univ, Sch Med, Dept Convergence Med Sci, Yangsan 50612, South Korea

[2] Pusan Natl Univ, Sch Biomed Convergence Engn, Yangsan 50612, South Korea

来源：

MATERIALS | 2021年 / 14卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

optical biosensors; circulating cancer biomarkers; optical transduction; metal nanoparticles (M-NPs); quantum dots (QDs); upconversion nanoparticles (UCNPs);

D O I：

10.3390/ma14061339

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The effectiveness of cancer treatment strongly depends on the early detection of the disease. Currently, the most common diagnostic method, tissue biopsy, takes time and can be damaging to the patient. Circulating cancer biomarkers such as circulating tumor DNA, micro-RNA (miRNA), tumor proteins, exosomes, and circulating tumor cells have repeatedly demonstrated their viability as targets for minimally invasive cancer detection through liquid biopsies. However, among other things, achieving a great sensitivity of detection is still challenging due to the very low concentration of biomarkers in fluid samples. This review will discuss how the recent advances in nanoparticle-based biosensors are overcoming these practical difficulties. This report will be focusing mainly on optical transduction mechanisms of metal nanoparticles (M-NPs), quantum dots (QDs), and upconversion nanoparticles (UCNPs).

引用

页数：18

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