TCGA2STAT: simple TCGA data access for integrated statistical analysis in R

被引:83
作者
Wan, Ying-Wooi [1 ,2 ]
Allen, Genevera I. [3 ,4 ]
Liu, Zhandong [1 ,4 ]
机构
[1] Baylor Coll Med, Computat & Integrat Biomed Res Ctr, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA
[3] Rice Univ, Dept Stat & Elect & Comp Engn, Houston, TX USA
[4] Texas Childrens Hosp, Baylor Coll Med, Jan & Dan Duncan Neurol Res Inst, Dept Pediat Neurol, Houston, TX 77030 USA
基金
美国国家科学基金会;
关键词
CANCER GENOMICS;
D O I
10.1093/bioinformatics/btv677
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Motivation: Massive amounts of high-throughput genomics data profiled from tumor samples were made publicly available by the Cancer Genome Atlas (TCGA). Results: We have developed an open source software package, TCGA2STAT, to obtain the TCGA data, wrangle it, and pre-process it into a format ready for multivariate and integrated statistical analysis in the R environment. In a user-friendly format with one single function call, our package downloads and fully processes the desired TCGA data to be seamlessly integrated into a computational analysis pipeline. No further technical or biological knowledge is needed to utilize our software, thus making TCGA data easily accessible to data scientists without specific domain knowledge.
引用
收藏
页码:952 / 954
页数:3
相关论文
共 5 条
[1]   The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data [J].
Cerami, Ethan ;
Gao, Jianjiong ;
Dogrusoz, Ugur ;
Gross, Benjamin E. ;
Sumer, Selcuk Onur ;
Aksoy, Buelent Arman ;
Jacobsen, Anders ;
Byrne, Caitlin J. ;
Heuer, Michael L. ;
Larsson, Erik ;
Antipin, Yevgeniy ;
Reva, Boris ;
Goldberg, Arthur P. ;
Sander, Chris ;
Schultz, Nikolaus .
CANCER DISCOVERY, 2012, 2 (05) :401-404
[2]   Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal [J].
Gao, Jianjiong ;
Aksoy, Buelent Arman ;
Dogrusoz, Ugur ;
Dresdner, Gideon ;
Gross, Benjamin ;
Sumer, S. Onur ;
Sun, Yichao ;
Jacobsen, Anders ;
Sinha, Rileen ;
Larsson, Erik ;
Cerami, Ethan ;
Sander, Chris ;
Schultz, Nikolaus .
SCIENCE SIGNALING, 2013, 6 (269) :pl1
[3]  
Lang Duncan Temple., 2013, XML: Tools for Parsing and Generating XML within R and S-Plus
[4]   RTCGAToolbox: A New Tool for Exporting TCGA Firehose Data [J].
Samur, Mehmet Kemal .
PLOS ONE, 2014, 9 (09)
[5]   canEvolve: A Web Portal for Integrative Oncogenomics [J].
Samur, Mehmet Kemal ;
Yan, Zhenyu ;
Wang, Xujun ;
Cao, Qingyi ;
Munshi, Nikhil C. ;
Li, Cheng ;
Shah, Parantu K. .
PLOS ONE, 2013, 8 (02)