CLOSING MITOSIS: The functions of the Cdc14 phosphatase and its regulation

被引：350
作者：
Stegmeier, F [1 ]
Amon, A [1 ]
机构：
[1] MIT, Howard Hughes Med Inst, Canc Res Ctr, Cambridge, MA 02139 USA
来源：
ANNUAL REVIEW OF GENETICS | 2004年 / 38卷
关键词：
FEAR; MEN; Cfi1/Net1; nucleolus;
D O I：
10.1146/annurev.genet.38.072902.093051
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Completion of the cell cycle requires the temporal and spatial coordination of chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding yeast, the protein phosphatase Cdc 14 is a key regulator of these late mitotic events. Here, we review the functions of Cdc 14 and how this phosphatase is regulated to accomplish the coupling of mitotic processes. We also discuss the function and regulation of Cdc 14 in other eukaryotes, emphasizing conserved features.
引用
收藏
页码：203 / 232
页数：30
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