Pleiotropy and the preservation of perfection

被引：105
作者：
Waxman, D
Peck, JR [1 ]
机构：
[1] Univ Sussex, Ctr Study Evolut, Brighton BN1 9QG, E Sussex, England
[2] Univ Sussex, Ctr Theoret Phys, Brighton BN1 9QG, E Sussex, England
[3] Univ Sussex, Sch Biol Sci, Brighton BN1 9QG, E Sussex, England
来源：
SCIENCE | 1998年 / 279卷 / 5354期
关键词：
D O I：
10.1126/science.279.5354.1210
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A mathematical model is presented in which a single mutation can affect multiple phenotypic characters, each of which is subject to stabilizing selection. A wide range of mutations is allowed, including ones that produce extremely small phenotypic changes. The analysis shows that, when three or more characters are affected by each mutation, a single optimal genetic sequence may become common. This result provides a hypothesis to explain the low levels of variation and low rates of substitution that are observed at some loci.
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收藏
页码：1210 / 1213
页数：4
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