Clinical Implications of Basic Science Discoveries: Janus Resurrected-Two Faces of B Cell and Plasma Cell Biology

被引：7

作者：

Woodle, E. S. ^{[1
]}

Rothstein, D. M. ^{[2
,3
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Surg, Div Transplantat, Cincinnati, OH USA

[2] Univ Pittsburgh, Sch Med, Dept Surg, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Sch Med, Dept Immunol, Thomas E Starzl Transplantat Inst, Pittsburgh, PA USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2015年 / 15卷 / 01期

关键词：

B cell biology; cellular biology; editorial; personal viewpoint; immune regulation; immunobiology; immunosuppression; immune modualtion; lymphocyte biology; plasma cells; B10; CELLS; T-CELLS; REJECTION; RITUXIMAB; THERAPY; AUTOIMMUNITY; IMMUNOPATHOGENESIS; TRANSPLANTATION; EXPRESSION; ANTIBODIES;

D O I：

10.1111/ajt.13028

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

B cells play a complex role in the immune response. In addition to giving rise to plasma cells (PCs) and promoting T cell responses via antigen presentation, they perform immunoregulatory functions. This knowledge has created concerns regarding nonspecific B cell depletional therapy because of the potential to paradoxically augment immune responses. Recent studies now indicate that PCs have immune functions beyond immunoglobulin synthesis. Evidence for a new role for PCs as potent regulatory cells (via IL-10 and IL-35 production) is discussed including the implications for PC-targeted therapies currently being developed for clinical transplantation. In this new feature, the authors discuss the recent article IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases (Nature 2014; 507: 366-370) and its implications for transplantation.

引用

页码：39 / 43

页数：5

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