Crystal Structure of the Oligomeric Form of Lassa Virus Matrix Protein Z

被引：26

作者：

Hastie, Kathryn M. ^{[1
]}

Zandonatti, Michelle ^{[1
]}

Liu, Tong ^{[2
,4
]}

Li, Sheng ^{[2
]}

Woods, Virgil L., Jr. ^{[2
]}

Saphire, Erica Ollmann ^{[1
,3
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[4] Sequenom, San Diego, CA USA

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 09期

基金：

美国国家卫生研究院;

关键词：

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; ARENAVIRUS Z PROTEIN; MASS-SPECTROMETRY; RING; REVEALS; VP40; TRANSLATION; EXCHANGE; PML;

D O I：

10.1128/JVI.02896-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The arenavirus matrix protein Z is highly multifunctional and occurs in both monomeric and oligomeric forms. The crystal structure of a dodecamer of Z from Lassa virus, presented here, illustrates a ring-like structure with a highly basic center. Mutagenesis demonstrates that the dimeric interface within the dodecamer and a Lys-Trp-Lys triad at the center of the ring are important for oligomerization. This structure provides an additional template to explore the many functions of Z.

引用

页码：4556 / 4562

页数：7

共 30 条

[1] PHENIX: a comprehensive Python']Python-based system for macromolecular structure solution
Adams, Paul D.
Afonine, Pavel V.
Bunkoczi, Gabor
Chen, Vincent B.
Davis, Ian W.
Echols, Nathaniel
Headd, Jeffrey J.
Hung, Li-Wei
Kapral, Gary J.
Grosse-Kunstleve, Ralf W.
McCoy, Airlie J.
Moriarty, Nigel W.
Oeffner, Robert
Read, Randy J.
Richardson, David C.
Richardson, Jane S.
Terwilliger, Thomas C.
Zwart, Peter H.
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2010, 66 : 213 - 221
[2] Electrostatics of nanosystems: Application to microtubules and the ribosome
Baker, NA
Sept, D
Joseph, S
Holst, MJ
McCammon, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) : 10037 - 10041
[3] Two RING finger proteins, the oncoprotein PML and the arenavirus Z protein, colocalize with the nuclear fraction of the ribosomal P proteins
Borden, KLB
Campbelldwyer, EJ
Carlile, GW
Djavani, M
Salvato, MS
[J]. JOURNAL OF VIROLOGY, 1998, 72 (05) : 3819 - 3826
[4] Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle
Bornholdt, Zachary A.
Noda, Takeshi
Abelson, Dafna M.
Halfmann, Peter
Wood, Malcolm R.
Kawaoka, Yoshihiro
Saphire, Erica Ollmann
[J]. CELL, 2013, 154 (04) : 763 - 774
[5] Arenavirus Z-glycoprotein association requires Z myristoylation but not functional RING or late domains
Capul, Althea A.
Perez, Mar
Burke, Emily
Kunz, Stefan
Buchmeier, Michael J.
de la Torre, Juan C.
[J]. JOURNAL OF VIROLOGY, 2007, 81 (17) : 9451 - 9460
[6] Conserved Residues in Lassa Fever Virus Z Protein Modulate Viral Infectivity at the Level of the Ribonucleoprotein
Capul, Althea A.
de la Torre, Juan Carlos
Buchmeier, Michael J.
[J]. JOURNAL OF VIROLOGY, 2011, 85 (07) : 3172 - 3178
[7] RING finger Z protein of lymphocytic choriomeningitis virus (LCMV) inhibits transcription and RNA replication of an LCMV S-segment minigenome
Cornu, TI
de la Torre, JC
[J]. JOURNAL OF VIROLOGY, 2001, 75 (19) : 9415 - 9426
[8] Crystal structure of the matrix protein VP40 from Ebola virus
Dessen, A
Volchkov, V
Dolnik, O
Klenk, HD
Weissenhorn, W
[J]. EMBO JOURNAL, 2000, 19 (16) : 4228 - 4236
[9] The lymphocytic choriomeningitis virus RING protein Z associates with eukaryotic initiation factor 4E and selectively represses translation in a RING-dependent manner
Dwyer, EJC
Lai, HK
MacDonald, RC
Salvato, MS
Borden, KLB
[J]. JOURNAL OF VIROLOGY, 2000, 74 (07) : 3293 - 3300
[10] Features and development of Coot
Emsley, P.
Lohkamp, B.
Scott, W. G.
Cowtan, K.
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2010, 66 : 486 - 501

← 1 2 3 →