The yeast Pdr5p multidrug transporter: How does it recognize so many substrates?

被引：45

作者：

Golin, John ^{[1
]}

Ambudkar, Suresh V.

May, Leopold

机构：

[1] Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA

[2] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[3] Catholic Univ Amer, Dept Chem, Washington, DC 20064 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 356卷 / 01期

关键词：

yeast multidrug resistance; Pdr5; ABC transporter; substrate specificity;

D O I：

10.1016/j.bbrc.2007.02.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multidrug transporters are of considerable importance because they present problems in the treatment of infectious disease and cancer. A central issue is the ability of efflux pumps to recognize an astounding array of structurally diverse compounds. The yeast Pdr5p efflux pump, which is a member of the ATP-binding cassette superfamily, has at least 3 substrate-binding sites, each of which appears to use different chemical properties to transport compounds. All Pdr5p substrates, however, have a size requirement that is independent of hydrophobicity. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1 / 5

页数：5

共 34 条

[1] The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1) [J].

Ambudkar, SV ;

Kim, IW ;

Sauna, ZE .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 27 (05) :392-400

[2] P-glycoprotein: from genomics to mechanism [J].

Ambudkar, SV ;

Kimchi-Sarfaty, C ;

Sauna, ZE ;

Gottesman, MM .

ONCOGENE, 2003, 22 (47) :7468-7485

[3]

BALZI E, 1994, J BIOL CHEM, V269, P2206

[4]

BISSINGER PH, 1994, J BIOL CHEM, V269, P4180

[5] ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p [J].

Decottignies, A ;

Grant, AM ;

Nichols, JW ;

de Wet, H ;

McIntosh, DB ;

Goffeau, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (20) :12612-12622

[6]

DECOTTIGNIES A, 1994, J BIOL CHEM, V269, P12797

[7] Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein [J].

Dey, S ;

Ramachandra, M ;

Pastan, I ;

Gottesman, MM ;

Ambudkar, SV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10594-10599

[8] Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter [J].

Egner, R ;

Rosenthal, FE ;

Kralli, A ;

Sanglard, D ;

Kuchler, K .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (02) :523-543

[9] On the mechanism of constitutive Pdr1 activator-mediated PDR5 transcription in Saccharomyces cerevisiae -: Evidence for enhanced recruitment of coactivators and altered nucleosome structures [J].

Gao, C ;

Wang, LM ;

Milgrom, E ;

Shen, WCW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (41) :42677-42686

[10] Quantification and characterization of P-glycoprotein-substrate interactions [J].

Gatlik-Landwojtowicz, E ;

Aänismaa, P ;

Seelig, A .

BIOCHEMISTRY, 2006, 45 (09) :3020-3032

← 1 2 3 4 →