Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions

被引：7
作者：
Sharma, Pawan K. [1 ]
Kumar, Rajiv [1 ,2 ]
Ram, Sita [1 ,3 ]
Chandak, Navneet [1 ]
机构：
[1] Kurukshetra Univ, Dept Chem, Kurukshetra, Haryana, India
[2] Ch Mani Ram Godara Govt Coll Women, Fatehabad, India
[3] JC Bose Univ Sci & Technol, Dept Chem, YMCA, Faridabad, India
来源：
SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 12期
关键词：
Aqueous ammonia; iodine; β -ketonitriles; 3-methoxypropenenitrile; one-pot; transition metal free; PD-CATALYZED CARBONYLATION; PHARMACOLOGICAL EVALUATION; ALPHA-CYANO; REDUCTION; BENZOYLACETONITRILES; INHIBITORS; CYCLIZATION; CYANIDES; KETONES; ESTERS;
D O I：
10.1080/00397911.2021.1910846
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one pot synthesis of beta-ketonitriles from readily accessible 3-chloropropenals using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for beta-ketonitriles.
引用
收藏
页码：1847 / 1856
页数：10
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