Prevalence of CCR5 and CCR2 HIV-coreceptor gene polymorphisms in Belgium

被引：26

作者：

Struyf, F

Thoelen, I

Charlier, N

Keyaerts, E

Van der Donck, I

Wuu, J

Van Ranst, M

机构：

[1] Rega Inst Med Res, Dept Microbiol & Immunol, Virol Lab, B-3000 Louvain, Belgium

[2] Univ Massachusetts, Ctr Canc, Div Biostat & Epidemiol, Worcester, MA 01605 USA

来源：

HUMAN HEREDITY | 2000年 / 50卷 / 05期

关键词：

CCR5; CCR2; chemokine receptors; polymorphism; HIV; acquired immunodeficiency syndrome; Belgium;

D O I：

10.1159/000022932

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Polymorphisms of the chemokine receptor genes CCR5 and CCR2 are associated with resistance to HIV-1 infection or delayed progression to AIDS. Few data are available on their combined prevalence in healthy subjects; we therefore examined the occurrence of CCR5-Delta 32 and CCR2-641 polymorphisms in a sample of 310 healthy Belgians. Allele frequencies were 0.119 and 0.074 for CCR5-Delta 32 and CCR2-641, respectively, Genotype distributions for both polymorphisms were found to be in accordance with Hardy-Weinberg equilibrium, but a significant (p = 0.002) linkage disequilibrium between CCR5-Delta 32 and CCR2-641 was observed. The high prevalence of CCR5-Delta 32 and CCR2-641 in Belgians may need to be taken into account in the design of studies of antiretroviral treatments, Copyright (C) 2000 S. Karger AG, Basel.

引用

收藏

页码：304 / 307

页数：4

相关论文

共 50 条

[21] Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis [J].

Zhao, XY ;

Gharizadeh, B ;

Hjelmström, P ;

Pirskanen, R ;

Nyrén, P ;

Lefvert, AK ;

Ghaderi, M .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2003, 12 (05) :749-753

[22] Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction [J].

P González ;

R Alvarez ;

A Batalla ;

JR Reguero ;

V Alvarez ;

A Astudillo ;

GI Cubero ;

A Cortina ;

E Coto .

Genes & Immunity, 2001, 2 :191-195

[23] Influence of CCR5 and CCR2 Genetic Variants in the Resistance/Susceptibility to HIV in Serodiscordant Couples from Colombia [J].

Zapata, Wildeman ;

Aguilar-Jimenez, Wbeimar ;

Pineda-Trujillo, Nicolas ;

Rojas, Winston ;

Estrada, Hernando ;

Rugeles, Maria T. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2013, 29 (12) :1594-1603

[24] Polymorphism of CC chemokine receptors CCR2 and CCR5 in Crohn's disease [J].

Herfarth, H ;

Pollok-Kopp, B ;

Göke, M ;

Press, A ;

Oppermann, M .

IMMUNOLOGY LETTERS, 2001, 77 (02) :113-117

[25] Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases [J].

Zhao, Qihong .

JOURNAL OF LEUKOCYTE BIOLOGY, 2010, 88 (01) :41-55

[26] SNP/haplotype associations of CCR2 and CCR5 genes with severity of chagasic cardiomyopathy [J].

Alejandra Machuca, Mayra ;

Uriel Suarez, Edwin ;

Eduardo Echeverria, Luis ;

Martin, Javier ;

Isabel Gonzalez, Clara .

HUMAN IMMUNOLOGY, 2014, 75 (12) :1210-1215

[27] Transmembrane Protein Aptamers That Inhibit CCR5 Expression and HIV Coreceptor Function [J].

Scheideman, Elizabeth H. ;

Marlatt, Sara A. ;

Xie, Yanhua ;

Hu, Yani ;

Sutton, Richard E. ;

DiMaio, Daniel .

JOURNAL OF VIROLOGY, 2012, 86 (19) :10281-10292

[28] Immunohistochemical analysis of CCR2, CCR3, CCR5, and CXCP4 in the human brain: Potential mechanisms for HIV dementia [J].

van der Meer, P ;

Ulrich, AM ;

Gonzalez-Scarano, F ;

Lavi, E .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2000, 69 (03) :192-201

[29] Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy [J].

Bowler, S. ;

Siriwardhana, C. ;

Mitchell, B. L. ;

D'Antoni, M. L. ;

Ogata-Arakaki, D. ;

Souza, S. ;

Yee, R. ;

Gangcuangco, L. M. A. ;

Chow, D. C. ;

Ndhlovu, L. C. ;

Shikuma, C. .

HIV RESEARCH & CLINICAL PRACTICE, 2019, 20 (4-5) :123-129

[30] CCR5 and HIV infection [J].

Blanpain, C ;

Libert, F ;

Vassart, G ;

Parmentier, M .

RECEPTORS & CHANNELS, 2002, 8 (01) :19-31

← 1 2 3 4 5 →