Efficacy of corneal cross-linking for the treatment of keratoconus

被引:1
作者
Touboul, D. [1 ]
Robinet-Perrin, A. [1 ]
Fournie, P. [2 ]
Malecaze, F. [2 ]
机构
[1] CHU Bordeaux, Ctr Reference Natl Keratocone CRNK, Batiment T,Pl Amelie Raba Leon, F-33000 Bordeaux, France
[2] CHU Toulouse, Hop Purpan, Ctr Reference Natl Keratocone CRNK, Serv Ophtalmol Pavillon Dieulafoy, Pl Docteur Baylac,TSA 40031, F-31059 Toulouse 9, France
来源
JOURNAL FRANCAIS D OPHTALMOLOGIE | 2016年 / 39卷 / 03期
关键词
Keratoconus; Cornea; Biomechanics; Viscoelasticity; Collages cross-linking; Riboflavin; BIOMECHANICAL PROPERTIES; EPITHELIUM-OFF; RIBOFLAVIN; ULTRAVIOLET; MICROSCOPY; RIBOFLAVIN/ULTRAVIOLET; PATTERN;
D O I
10.1016/j.jfo.2015.12.002
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Keratoconus (KC) is a complex disease whose pathophysiology is only partially understood. The priority in management is to halt the progression of corneal deformation as soon as possible in the course of KC disease. Corneal cross-linking (CXL) is at present the only dedicated treatment for this purpose. Its biochemical mechanism of action leads to changes in the viscoelastic properties of the cornea induced by matrix bonding and renewal of keratocytes. The effect of CXL is difficult to quantify when measured in in-vivo conditions because of a lack of consistent tools adapted for clinical practice. Nevertheless, a large amount of evidence has been collected so far confirming the positive action of CXL on corneal structural reinforcement, and numerous studies have demonstrated significant efficacy in halting progression of KC with long-term follow-up. Published studies, however, are of relatively low scientific power given the great heterogeneity of the disease and the numerous associated biases in evaluation. The purpose of this paper is to summarize the consistent evidence of efficacy of CXL and to justify its role in our therapeutic armamentarium for management of progressive KC. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:308 / 314
页数:7
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