Insights into cytokine release syndrome and neurotoxicity after CD19-specific CAR-T cell therapy

被引：110
作者：
Gauthier, Jordan [1 ]
Turtle, Cameron J. [1 ,2 ]
机构：
[1] Fred Hutchinson Canc Res Ctr, Clin Res Div, 1100 Fairview Ave N, Seattle, WA 98109 USA
[2] Fred Hutchinson Canc Res Ctr, Dept Med, Seattle, WA 98104 USA
来源：
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE | 2018年 / 66卷 / 02期
关键词：
Review; Chimeric antigen receptor therapy; Hematological malignancies; Adoptive t-cell therapy; Cytokine release syndrome; Neurotoxicity; LYMPHOBLASTIC-LEUKEMIA; YOUNG-ADULTS; B-CELL; REMISSIONS; CHILDREN;
D O I：
10.1016/j.retram.2018.03.003
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
T-cells engineered to express CD19-specific chimeric antigen receptors (CD19 CAR-T cells) can achieve high response rates in patients with refractory/relapsed (R/R) CD19+ hematologic malignancies. Nonetheless, the efficacy of CD19-specific CAR-T cell therapy can be offset by significant toxicities, such as cytokine release syndrome (CRS) and neurotoxicity. In this report of our presentation at the 2018 Second French International Symposium on CAR-T cells (CAR-T day), we describe the clinical presentations of CRS and neurotoxicity in a cohort of 133 adults treated with CD19 CAR-T cells at the Fred Hutchinson Cancer Research Center, and provide insights into the mechanisms contributing to these toxicities. (C) 2018 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：50 / 52
页数：3
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