Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles

被引：42

作者：

Sumesh, Remani Vasudevan ^{[1
]}

Muthu, Muthumani ^{[1
]}

Almansour, Abdulrahman I. ^{[2
]}

Kumar, Raju Suresh ^{[2
]}

Arumugam, Natarajan ^{[2
]}

Athimoolam, S. ^{[3
]}

Prabha, E. Arockia Jeya Yasmi ^{[3
]}

Kumar, Raju Ranjith ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

[2] King Saud Univ, Dept Chem, Coll Sci, POB 2455, Riyadh 11451, Saudi Arabia

[3] Anna Univ, Constituent Coll, Dept Phys, Univ Coll Engn, Nagercoil 629004, Tamil Nadu, India

来源：

ACS COMBINATORIAL SCIENCE | 2016年 / 18卷 / 05期

关键词：

1,3-dipolar cycloaddition; azomethine ylide; alpha-amino acid; isatin; pyrazolo[3,4-b]quinoline; spiro-oxindole; spiro-pyrrolidine; CELL CYCLE INHIBITORS; ASPERGILLUS-FUMIGATUS; EFFICIENT SYNTHESIS; ONE-POT; DERIVATIVES; DISCOVERY; ISORHYNCHOPHYLLINE; RHYNCHOPHYLLINE; ANALOGS; ISATIN;

D O I：

10.1021/acscombsci.6b00003

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline pyrrolidine/pyrrolothiazole/indolizine oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from a amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo [3,4-b]quinoline derivatives.

引用

页码：262 / 270

页数：9

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