Dynamic Cross-Linking Is Retained in Duplex DNA after Multiple Exchange of Strands

被引：69
作者：
Wang, Huan [1 ]
Rokita, Steven E. [1 ]
机构：
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 34期
基金：
美国国家科学基金会;
关键词：
alkylation; DNA; DNA cross-linking; dynamic covalent reactions; quinone methides; QUINONE METHIDES; ALKYLATION; CHEMISTRY; ADDUCTS; POTENT; NANOTECHNOLOGY; DUOCARMYCIN; ALDEHYDES; AGENTS;
D O I：
10.1002/anie.201001597
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Figure Presented Strands may come and go, but crosslinking is forever: Dynamic combinatorial chemistry can respond to changing environments, a characteristic that is now demonstrated with DNA cross-linking based on reversible alkylation of a quinone methide intermediate (see picture). © 2010 wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：5957 / 5960
页数：4
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