Dynamic Cross-Linking Is Retained in Duplex DNA after Multiple Exchange of Strands

被引：69

作者：

Wang, Huan ^{[1
]}

Rokita, Steven E. ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 34期

基金：

美国国家科学基金会;

关键词：

alkylation; DNA; DNA cross-linking; dynamic covalent reactions; quinone methides; QUINONE METHIDES; ALKYLATION; CHEMISTRY; ADDUCTS; POTENT; NANOTECHNOLOGY; DUOCARMYCIN; ALDEHYDES; AGENTS;

D O I：

10.1002/anie.201001597

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Figure Presented Strands may come and go, but crosslinking is forever: Dynamic combinatorial chemistry can respond to changing environments, a characteristic that is now demonstrated with DNA cross-linking based on reversible alkylation of a quinone methide intermediate (see picture). © 2010 wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5957 / 5960

页数：4

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