Effects of sevoflurane and propofol on pulmonary shunt fraction during one-lung ventilation for thoracic surgery

被引:57
作者
Beck, DH [1 ]
Doepfmer, UR [1 ]
Sinemus, C [1 ]
Bloch, A [1 ]
Schenk, MR [1 ]
Kox, WJ [1 ]
机构
[1] Univ berlin, Klin Charite, Abt Anaesthesiol & Operat Intens Med, D-10117 Berlin, Germany
关键词
lung; hypoxic pulmonary vasoconstriction; anaesthetics i.v; propofol; anaesthetics volatile; sevoflurane; pulmonary shunt fraction; surgery; thoracic;
D O I
10.1093/bja/86.1.38
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Forty patients requiring one-lung ventilation (OLV) for thoracic surgery were randomly assigned to receive propofol (4-6 mg kg(-1) h(-1)) or sevoflurane (1 MAC) for maintenance of anaesthesia. Three sets of measurements were taken: (i) after 30 min of two-lung ventilation (TLV), (ii) after 30 min of one-lung ventilation (OLV-1) in the supine position and (iii) during OLV in the lateral position (OLV-2) with the chest open and before surgical manipulation of the lung. There were no differences between groups in patient characteristics or preoperative condition. Increases in shunt fraction during OLV-1 were 17.4% and 17.2% (P=0.94), those during OLV-2 were 18.3% and 16.5% (P=0.59) for the propofol and sevoflurane group, respectively. Cardiac index and other haemodynamic and respiratory variables were similar for the two groups. We conclude that inhibition of hypoxic pulmonary vasoconstriction by sevoflurane may only account for small increases in shunt fraction and that much of the overall shunt fraction during OLV has other causes.
引用
收藏
页码:38 / 43
页数:6
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