MR Fingerprinting for Rapid Quantitative Abdominal Imaging

被引:167
作者
Chen, Yong [1 ]
Jiang, Yun [2 ]
Pahwa, Shivani [1 ]
Ma, Dan [1 ]
Lu, Lan [1 ]
Twieg, Michael D. [3 ]
Wright, Katherine L. [1 ]
Seiberlich, Nicole [2 ]
Griswold, Mark A. [1 ,2 ]
Gulani, Vikas [1 ]
机构
[1] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Radiol, 11100 Euclid Ave,Bolwell Bldg,Room B120, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Biomed Engn, 11100 Euclid Ave,Bolwell Bldg,Room B120, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Elect Engn & Comp Sci, 11100 Euclid Ave,Bolwell Bldg,Room B120, Cleveland, OH 44106 USA
基金
美国国家卫生研究院;
关键词
RELAXATION-TIMES; T-2; RELAXATION; PRECLINICAL MR; IN-VIVO; LIVER; METASTASES; LESIONS;
D O I
10.1148/radiol.2016152037
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To develop a magnetic resonance (MR) "fingerprinting" technique for quantitative abdominal imaging. Materials and Methods: This HIPAA-compliant study had institutional review board approval, and informed consent was obtained from all subjects. To achieve accurate quantification in the presence of marked B-0 and B-1 field inhomogeneities, the MR fingerprinting framework was extended by using a two-dimensional fast imaging with steady-state free precession, or FISP, acquisition and a Bloch-Siegert B-1 mapping method. The accuracy of the proposed technique was validated by using agarose phantoms. Quantitative measurements were performed in eight asymptomatic subjects and in six patients with 20 focal liver lesions. A two-tailed Student t test was used to compare the T1 and T2 results in metastatic adenocarcinoma with those in surrounding liver parenchyma and healthy subjects. Results: Phantom experiments showed good agreement with standard methods in T1 and T2 after B-1 correction. In vivo studies demonstrated that quantitative T1, T2, and B-1 maps can be acquired within a breath hold of approximately 19 seconds. T1 and T2 measurements were compatible with those in the literature. Representative values included the following: liver, 745 msec +/- 65 (standard deviation) and 31 msec +/- 6; renal medulla, 1702 msec 6 205 and 60 msec +/- 21; renal cortex, 1314 msec +/- 77 and 47 msec +/- 10; spleen, 1232 msec +/- 92 and 60 msec 6 19; skeletal muscle, 1100 msec +/- 59 and 44 msec +/- 9; and fat, 253 msec +/- 42 and 77 msec +/- 16, respectively. T1 and T2 in metastatic adenocarcinoma were 1673 msec 6 331 and 43 msec +/- 13, respectively, significantly different from surrounding liver parenchyma relaxation times of 840 msec +/- 113 and 28 msec +/- 3 (P < .0001 and P < .01) and those in hepatic parenchyma in healthy volunteers (745 msec +/- 65 and 31 msec +/- 6, P < .0001 and P = .021, respectively). Conclusion: A rapid technique for quantitative abdominal imaging was developed that allows simultaneous quantification of multiple tissue properties within one 19-second breath hold, with measurements comparable to those in published literature. (C) RSNA, 2016
引用
收藏
页码:278 / 286
页数:9
相关论文
共 28 条
[1]   Clinical Applications of Dual-Channel Transmit MRI: A Review [J].
Brink, Wyger M. ;
Gulani, Vikas ;
Webb, Andrew G. .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2015, 42 (04) :855-869
[2]  
Chen Y, 2015, MAGN RESON MED
[3]   MR vascular fingerprinting: A new approach to compute cerebral blood volume, mean vessel radius, and oxygenation maps in the human brain [J].
Christen, T. ;
Pannetier, N. A. ;
Ni, W. W. ;
Qiu, D. ;
Moseley, M. E. ;
Schuff, N. ;
Zaharchuk, G. .
NEUROIMAGE, 2014, 89 :262-270
[4]   MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: Preliminary results [J].
de Bazelaire, CMJ ;
Duhamel, GD ;
Rofsky, NM ;
Alsop, DC .
RADIOLOGY, 2004, 230 (03) :652-659
[5]   Simple correction method for k-space trajectory deviations in MRI [J].
Duyn, JH ;
Yang, YH ;
Frank, JA ;
van der Veen, JW .
JOURNAL OF MAGNETIC RESONANCE, 1998, 132 (01) :150-153
[6]   Magnetic Resonance Fingerprinting - a promising new approach to obtain standardized imaging biomarkers from MRI [J].
European Society of Radiology .
Insights into Imaging, 2015, 6 (2) :163-165
[7]   Signal characteristics of focal liver lesions on double echo T2-weighted conventional spin echo MRI: Observer performance versus quantitative measurements of T2 relaxation times [J].
Fenlon, HM ;
Tello, R ;
deCarvalho, VLS ;
Yucel, EK .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2000, 24 (02) :204-211
[8]   Measurements of T1 and T2 relaxation times of colon cancer metastases in rat liver at 7T [J].
Gambarota, G ;
Veltien, A ;
van Laarhoven, H ;
Philippens, M ;
Jonker, A ;
Mook, OR ;
Frederiks, WM ;
Heerschap, A .
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 2004, 17 (3-6) :281-287
[9]   Preclinical MR fingerprinting (MRF) at 7 T: effective quantitative imaging for rodent disease models [J].
Gao, Ying ;
Chen, Yong ;
Ma, Dan ;
Jiang, Yun ;
Herrmann, Kelsey A. ;
Vincent, Jason A. ;
Dell, Katherine M. ;
Drumm, Mitchell L. ;
Brady-Kalnay, Susann M. ;
Griswold, Mark A. ;
Flask, Chris A. ;
Lu, Lan .
NMR IN BIOMEDICINE, 2015, 28 (03) :384-394
[10]   VALUE OF T1-RELAXATION AND T2-RELAXATION TIMES FROM ECHOPLANAR MR IMAGING IN THE CHARACTERIZATION OF FOCAL HEPATIC-LESIONS [J].
GOLDBERG, MA ;
HAHN, PF ;
SAINI, S ;
COHEN, MS ;
REIMER, P ;
BRADY, TJ ;
MUELLER, PR .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1993, 160 (05) :1011-1017