Emerging roles for MEF2 in brain development and mental disorders

被引：47
作者：
Assali, Ahlem [1 ]
Harrington, Adam J. [1 ]
Cowan, Christopher W. [1 ]
机构：
[1] Med Univ South Carolina, Dept Neurosci, 173 Ashley Ave, Charleston, SC 29425 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2019年 / 59卷
关键词：
TRANSCRIPTION FACTOR MEF2C; ENHANCER-BINDING FACTOR; RETARDATION PROTEIN; NEURONAL-ACTIVITY; GENE-EXPRESSION; FACTOR; 2C; SYNAPSE ELIMINATION; FACTOR FAMILY; PHOSPHORYLATION; MUSCLE;
D O I：
10.1016/j.conb.2019.04.008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The MEF2 family of transcription factors regulate large programs of gene expression important for the development and maintenance of many tissues, including the brain. MEF2 proteins are regulated by neuronal synaptic activity, and they recruit several epigenetic enzymes to influence chromatin structure and gene expression during development and throughout adulthood. Here, we provide a brief review of the recent literature reporting important roles for MEF2 during early brain development and function, and we highlight emerging roles for MEF2 as a risk factor for multiple neurodevelopmental disorders and mental illnesses, such as autism, intellectual disability, and schizophrenia.
引用
收藏
页码：49 / 58
页数：10
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