Emerging roles for MEF2 in brain development and mental disorders

被引：52

作者：

Assali, Ahlem ^{[1
]}

Harrington, Adam J. ^{[1
]}

Cowan, Christopher W. ^{[1
]}

机构：

[1] Med Univ South Carolina, Dept Neurosci, 173 Ashley Ave, Charleston, SC 29425 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2019年 / 59卷

关键词：

TRANSCRIPTION FACTOR MEF2C; ENHANCER-BINDING FACTOR; RETARDATION PROTEIN; NEURONAL-ACTIVITY; GENE-EXPRESSION; FACTOR; 2C; SYNAPSE ELIMINATION; FACTOR FAMILY; PHOSPHORYLATION; MUSCLE;

D O I：

10.1016/j.conb.2019.04.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The MEF2 family of transcription factors regulate large programs of gene expression important for the development and maintenance of many tissues, including the brain. MEF2 proteins are regulated by neuronal synaptic activity, and they recruit several epigenetic enzymes to influence chromatin structure and gene expression during development and throughout adulthood. Here, we provide a brief review of the recent literature reporting important roles for MEF2 during early brain development and function, and we highlight emerging roles for MEF2 as a risk factor for multiple neurodevelopmental disorders and mental illnesses, such as autism, intellectual disability, and schizophrenia.

引用

页码：49 / 58

页数：10

共 108 条

[1] Metaplasticity: The plasticity of synaptic plasticity [J].

Abraham, WC ;

Bear, MF .

TRENDS IN NEUROSCIENCES, 1996, 19 (04) :126-130

[2] Postnatal Loss of Mef2c Results in Dissociation of Effects on Synapse Number and Learning and Memory [J].

Adachi, Megumi ;

Lin, Pei-Yi ;

Pranav, Heena ;

Monteggia, Lisa M. .

BIOLOGICAL PSYCHIATRY, 2016, 80 (02) :140-148

[3] In Vivo Analysis of MEF2 Transcription Factors in Synapse Regulation and Neuronal Survival [J].

Akhtar, M. Waseem ;

Kim, Mi-Sung ;

Adachi, Megumi ;

Morris, Michael J. ;

Qi, Xiaoxia ;

Richardson, James A. ;

Bassel-Duby, Rhonda ;

Olson, Eric N. ;

Kavalali, Ege T. ;

Monteggia, Lisa M. .

PLOS ONE, 2012, 7 (04)

[4] DETERMINATION OF THE CONSENSUS BINDING-SITE FOR MEF2 EXPRESSED IN MUSCLE AND BRAIN REVEALS TISSUE-SPECIFIC SEQUENCE CONSTRAINTS [J].

ANDRES, V ;

CERVERA, M ;

MAHDAVI, V .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (40) :23246-23249

[5] Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells [J].

Angelelli, Cecilia ;

Magli, Alessandro ;

Ferrari, Daniela ;

Ganassi, Massimo ;

Matafora, Vittoria ;

Parise, Flavia ;

Razzini, Giorgia ;

Bachi, Angela ;

Ferrari, Stefano ;

Molinari, Susanna .

NUCLEIC ACIDS RESEARCH, 2008, 36 (03) :915-928

[6] Evolution of Osteocrin as an activity-regulated factor in the primate brain [J].

Ataman, Bulent ;

Boulting, Gabriella L. ;

Harmin, David A. ;

Yang, Marty G. ;

Baker-Salisbury, Mollie ;

Yap, Ee-Lynn ;

Malik, Athar N. ;

Mei, Kevin ;

Rubin, Alex A. ;

Spiegel, Ivo ;

Durresi, Ershela ;

Sharma, Nikhil ;

Hu, Linda S. ;

Pletikos, Mihovil ;

Griffith, Eric C. . ;

Partlow, Jennifer N. ;

Stevens, Christine R. ;

Adli, Mazhar ;

Chahrour, Maria ;

Sestan, Nenad ;

Walsh, Christopher A. ;

Berezovskii, Vladimir K. ;

Livingstone, Margaret S. ;

Greenberg, Michael E. .

NATURE, 2016, 539 (7628) :242-+

[7] Phosphorylation-dependent degradation of MEF2C contributes to regulate G2/M transition [J].

Badodi, Sara ;

Baruffaldi, Fiorenza ;

Ganassi, Massimo ;

Battini, Renata ;

Molinari, Susanna .

CELL CYCLE, 2015, 14 (10) :1517-1528

[8] MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function [J].

Barbosa, Ana C. ;

Kim, Mi-Sung ;

Ertunc, Mert ;

Adachi, Megumi ;

Nelson, Erika D. ;

McAnally, John ;

Richardson, James A. ;

Kavalali, Ege T. ;

Monteggia, Lisa M. ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (27) :9391-9396

[9] Dynamic Phosphorylation of the Myocyte Enhancer Factor 2Cα1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy [J].

Baruffaldi, Fiorenza ;

Montarras, Didier ;

Basile, Valentina ;

De Feo, Luca ;

Badodi, Sara ;

Ganassi, Massimo ;

Battini, Renata ;

Nicoletti, Carmine ;

Imbriano, Carol ;

Musaro, Antonio ;

Molinari, Susanna .

STEM CELLS, 2017, 35 (03) :725-738

[10] The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition [J].

Bloodgood, Brenda L. ;

Sharma, Nikhil ;

Browne, Heidi Adlman ;

Trepman, Alissa Z. ;

Greenberg, Michael E. .

NATURE, 2013, 503 (7474) :121-+

← 1 2 3 4 5 6 7 8 9 10 →