Can stem cells mend a broken heart?

被引：48

作者：

Davani, S ^{[1
]}

Deschaseaux, F

Chalmers, D

Tiberghien, P

Kantelip, JP

机构：

[1] CHU Jean Minjoz, Pharmacol Lab, EA 479,IFR 133, Fac Med, F-25000 Besancon, France

[2] INSERM, Etab Francais Sang Bourgogne Franche Comte, EA 2284, U 645,IFR 133, Besancon, France

来源：

CARDIOVASCULAR RESEARCH | 2005年 / 65卷 / 02期

关键词：

heart failure; infarction; stem cells; ventricular function;

D O I：

10.1016/j.cardiores.2004.10.037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myocardial infarction is the leading cause of heart failure in developed countries. The therapeutic measures of today are usually not sufficient to prevent left ventricular remodelling as they fall short of actual replacement of necrotic cardiac myocytes. However, current insights into stem cell plasticity have opened up new perspectives for regenerating the infarcted heart. Recently, a wide range of stem/progenitor cell types have been used for cardiac cell therapy (CCT), including embryonic or foetal stem cells, myoblasts, and bone marrow stem cells. To date, the choice of stem cells has yet to be optimised. This review details recent experimental data and discusses the clinical potential of the various stem cell sources for CCT. (C) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：305 / 316

页数：12

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