Targeting BDNF signaling by natural products: Novel synaptic repair therapeutics for neurodegeneration and behavior disorders

被引：42

作者：

Bawari, Sweta ^{[1
]}

Tewari, Devesh ^{[2
]}

Arguelles, Sandro ^{[3
]}

Sah, Archana N. ^{[4
]}

Nabavi, Seyed Fazel ^{[5
]}

Xu, Suowen ^{[6
]}

Vacca, Rosa Anna ^{[7
]}

Nabavi, Seyed Mohammad ^{[5
]}

Shirooie, Samira ^{[8
]}

机构：

[1] Sharda Univ, Sch Pharm, Knowledge Park III, Greater Noida 201310, Uttar Pradesh, India

[2] Lovely Profess Univ, Sch Pharmaceut Sci, Dept Pharmacognosy, Phagwara 144411, Punjab, India

[3] Univ Seville, Dept Physiol, Seville, Spain

[4] Kumaun Univ, Fac Technol, Dept Pharmaceut Sci, Bltimtal Campus, Naini Tal 263136, Uttarakhand, India

[5] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran

[6] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA

[7] CNR, Inst Biomembranes Bioenerget & Mol Biotechnol, I-170126 Bari, Italy

[8] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah 6734667149, Iran

来源：

PHARMACOLOGICAL RESEARCH | 2019年 / 148卷

关键词：

Brain; Dementia; Neurodegeneration; Synapses; BDNF; NEUROTROPHIC FACTOR BDNF; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; LONG-TERM POTENTIATION; GENE VAL66MET POLYMORPHISM; AUTISTIC-LIKE BEHAVIORS; GREEN TEA POLYPHENOLS; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; MOLECULAR PATHOGENESIS;

D O I：

10.1016/j.phrs.2019.104458

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neurodegenerative disorders like Alzheimer's disease, Huntington's disease, Parkinson's disease, spinocerebellar ataxias, amyotrophic lateral sclerosis, frontotemporal dementia to prion diseases, Friedreich's ataxia, hereditary spastic paraplegia and optic atrophy type 1, and behavior disorders like neuropsychiatric, hyperactivity and autism spectrum disorders are closely associated with neurobiological deficits. Brain derived neurotrophic factor (BDNF) is an extensively studied neurotrophin. BDNF is essential for neuronal genesis, differentiation, survival, growth, plasticity, synaptic viability and transmission. BDNF has emerged as a promising target for regulating synaptic activity and plasticity. An overview of effects and mechanisms of the natural products targeting BDNF is described. This review is an attempt to enumerate the effects of various natural products on BDNF as a novel therapeutic approach for neurodegenerative and neuropsychiatric disorders.

引用

页数：14

共 244 条

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