Total synthesis and preliminary antibacterial evaluation of the RNA polymerase inhibitors (±)-myxopyronin A and B

被引：39

作者：

Hu, T

Schaus, JV

Lam, K

Palfreyman, MG

Wuonola, M

Gustafson, G

Panek, JS

机构：

[1] Boston Univ, Metcalf Ctr Sci & Engn, Dept Chem, Boston, MA 02215 USA

[2] Scriptgen Pharmaceut Inc, Medford, MA 02155 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 07期

关键词：

D O I：

10.1021/jo9721610

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[No abstract available]

引用

页码：2401 / 2406

页数：6

共 14 条

[1] INHIBITION OF HUMAN SPUTUM ELASTASE BY SUBSTITUTED 2-PYRONES .2. [J].

COOK, L ;

TERNAI, B ;

GHOSH, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (06) :1017-1023

[2] A USEFUL 12-I-5 TRIACETOXYPERIODINANE (THE DESS-MARTIN PERIODINANE) FOR THE SELECTIVE OXIDATION OF PRIMARY OR SECONDARY ALCOHOLS AND A VARIETY OF RELATED 12-I-5 SPECIES [J].

DESS, DB ;

MARTIN, JC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (19) :7277-7287

[3] READILY ACCESSIBLE 12-I-5 OXIDANT FOR THE CONVERSION OF PRIMARY AND SECONDARY ALCOHOLS TO ALDEHYDES AND KETONES [J].

DESS, DB ;

MARTIN, JC .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (22) :4155-4156

[4]

Griffith W.P., 1990, Aldrichim Acta, V23, P13

[5] AN IMPROVED PROCEDURE FOR THE PREPARATION OF THE DESS-MARTIN PERIODINANE [J].

IRELAND, RE ;

LIU, LB .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (10) :2899-2899

[6] THE MYXOPYRONINS, NEW INHIBITORS OF BACTERIAL RNA-SYNTHESIS FROM MYXOCOCCUS-FULVUS (MYXOBACTERALES) [J].

IRSCHIK, H ;

GERTH, K ;

HOFLE, G ;

KOHL, W ;

REICHENBACH, H .

JOURNAL OF ANTIBIOTICS, 1983, 36 (12) :1651-1658

[7]

JANSEN R, 1985, LIEBIGS ANN CHEM, P822

[8]

KOHL W, 1984, LIEBIGS ANN CHEM, P1088

[9]

KOHL W, 1983, LIEBIGS ANN CHEM, P1656

[10]

LEY SV, 1994, SYNTHESIS-STUTTGART, P639

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