Titanium-catalyzed hydroamination of propargyl alcohol derivatives: Synthesis of 3-silyloxy-2-methylindoles via hydrohydrazination

被引：46

作者：

Schwarz, Nicolle ^{[1
]}

Alex, Karolin ^{[1
]}

Sayyed, Iliyas Ali ^{[1
]}

Khedkar, Vivek ^{[1
]}

Tillack, Annegret ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse 5, D-18059 Rostock, Germany

来源：

SYNLETT | 2007年 / 07期

关键词：

alkyne; hydrazine; hydroamination; indole; titanium;

D O I：

10.1055/s-2007-973892

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method for the one-pot synthesis of substituted 3-(tert-butyidimethylsilyloxy)indoles via hydrohydrazination of alkynes and subsequent Fischer indole synthesis has been developed. For the first time titanium-catalyzed hydroaminations of propargyl alcohol derivatives are shown.

引用

页码：1091 / 1095

页数：5

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