A new indole alkaloid with anti-inflammatory activity from Nauclea officinalis

被引：40

作者：

Liu, Qing-Long ^{[1
,2
]}

Chen, A-Hong ^{[1
,2
]}

Tang, Jin-Ying ^{[1
,2
]}

Ma, Yan-Lei ^{[1
,2
]}

Jiang, Zhi-Hua ^{[1
,2
]}

Liu, Yan-Ping ^{[2
]}

Chen, Guang-Ying ^{[1
,2
]}

Fu, Yan-Hui ^{[1
,2
]}

Xu, Wei ^{[1
]}

机构：

[1] Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou, Fujian, Peoples R China

[2] Hainan Normal Univ, Minist Educ, Key Lab Trop Med Plant Chem, Haikou, Hainan, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 18期

基金：

中国国家自然科学基金;

关键词：

Nauclea officinalis; indole alkaloid; anti-inflammatory activity; nitric oxide production; STRICTOSAMIDE;

D O I：

10.1080/14786419.2016.1277351

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new indole alkaloid, 17-O-methyl-19-(Z)-naucline (1), together with seven known alkaloids (2-8), were isolated from the stems and leaves of Nauclea officinalis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literature. 17-O-methyl-19-(Z)-naucline (1) showed significant inhibitory activity on nitric oxide production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with an IC50 value of 3.6 mu M. [GRAPHICS] .

引用

页码：2107 / 2112

页数：6

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