Chirality - A new era of therapeutics

被引:37
作者
Agrawal, Y. K.
Bhatt, H. G.
Raval, H. G.
Oza, P. M.
Gogoi, P. J.
机构
[1] NIRMA Univ, Inst Pharm, Ahmadabad 382481, Gujarat, India
[2] Anand Pharm Coll, Anand 388001, Gujarat, India
关键词
chirality; enantiomers; stereoselectivity; racemic switching; drug combination; pharmacokinetics;
D O I
10.2174/138955707780619617
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
To develop the newer pharmaceuticals and to spur the strong growth, being a general property of `handedness' chirality plays a major role. The Easson-Stedman principle shows the differences in the biological activity between enantiomers resulted from selective reactivity of one enantiomer with its receptor. It helps to improve the pharmacokinetic properties and to remove undesirable side effects by virtue of the unique activity of enantiomers. Racemic switching and marketing drug combinations are used as tools for drug life-cycle management and to redevelop racemic mixtures as single enantiomers.
引用
收藏
页码:451 / 460
页数:10
相关论文
共 54 条
[1]  
AITKEN RA, 1995, ASYMMETRIC SYNTHESIS, P64
[2]   NONCHIRAL, HOMOCHIRAL AND COMPOSITE CHIRAL DRUGS [J].
ARIENS, EJ .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (02) :68-75
[3]  
BLASCHKE G, 1979, ARZNEIMITTEL-FORSCH, V29-2, P1640
[4]   STEREOSPECIFIC DETERMINATION OF THE IN-VITRO DISSOLUTION OF MODIFIED RELEASE FORMULATIONS OF (+/-)-VERAPAMIL [J].
CARR, RA ;
PASUTTO, FM ;
LONGSTRETH, JA ;
FOSTER, RT .
CHIRALITY, 1993, 5 (06) :443-447
[5]   Studies on the relationship between chemical constitution and physiological action. V. Molecular dissymmetry and physiological activity. [J].
Easson, LH ;
Stedman, E .
BIOCHEMICAL JOURNAL, 1933, 27 :1257-1266
[6]  
EICHELBAUM M, 1996, ADV DRUG RES, V28, P2
[7]   THE EFFECT OF SATURABLE BINDING TO PLASMA-PROTEINS ON THE PHARMACOKINETIC PROPERTIES OF DISOPYRAMIDE [J].
GIACOMINI, KM ;
SWEZEY, SE ;
TURNERTAMIYASU, K ;
BLASCHKE, TF .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1982, 10 (01) :1-14
[8]   COMPARATIVE ANTICHOLINERGIC POTENCIES OF R-DISOPYRAMIDE AND S-DISOPYRAMIDE IN LONGITUDINAL MUSCLE STRIPS FROM GUINEA-PIG ILEUM [J].
GIACOMINI, KM ;
COX, BM ;
BLASCHKE, TF .
LIFE SCIENCES, 1980, 27 (13) :1191-1197
[9]   INVIVO INTERACTION OF THE ENANTIOMERS OF DISOPYRAMIDE IN HUMAN-SUBJECTS [J].
GIACOMINI, KM ;
NELSON, WL ;
PERSHE, RA ;
VALDIVIESO, L ;
TURNERTAMIYASU, K ;
BLASCHKE, TF .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1986, 14 (04) :335-356
[10]   ENANTIOSELECTIVE GALLOPAMIL PROTEIN-BINDING [J].
GROSS, AS ;
ESER, C ;
MIKUS, G ;
EICHELBAUM, M .
CHIRALITY, 1993, 5 (06) :414-418