CO2 is converted to methanol through an enzymatic approach using formate dehydrogenase (FateDH), formaldehyde dehydrogenase (FaldDH) and alcohol dehydrogenase (ADH) co-encapsulated in silica gel prepared by modified sol-gel process as catalysts, TEOS as precursor, NADH as an electron donor. The highest yield of methanol was up to 92.1% under 37degreesC, pH7.0 and 0.3Mpa.