Observation of short wavelength infrared (SWIR ) Cherenkov emission

被引：17

作者：

Cao, Xu ^{[1
,2
,3
]}

Jiang, Shudong ^{[1
]}

Jia, Mengyu ^{[1
]}

Gunn, Jason ^{[1
]}

Miao, Tianshun ^{[1
]}

Davis, Scott C. ^{[1
]}

Bruza, Petr ^{[1
]}

Pogue, Brian W. ^{[1
]}

机构：

[1] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA

[2] Xidian Univ, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China

[3] Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China

来源：

OPTICS LETTERS | 2018年 / 43卷 / 16期

基金：

美国国家卫生研究院;

关键词：

THERAPY; WINDOW; TIME;

D O I：

10.1364/OL.43.003854

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Cherenkov emission induced by external beam radiation from a clinical linear accelerator has been shown in preclinical molecular imaging and clinical imaging. The broad spectrum Cherenkov emission should have a short wavelength infrared (SWIR, 1000-1700 nm) component, as predicted theoretically. To the best of our knowledge, this Letter is the first experimental observation of this SWIR Cherenkov emission induced by external beam radiation. The measured spectrum of SWIR Cherenkov emission matches the theoretical prediction, with a fluence rate near one-third of the visible and near-infrared red emissions (Vis-NIR, 400-900 nm). Imaging in water-based phantoms and biological tissues indicates that there is a sufficient fluence rate for radiotherapy dosimetry applications. The spatial resolution is improved approximately 5.3 times with SWIR Cherenkov emission detection versus Vis-NIR Cherenkov emission, which provides some improvement in the potential for higher resolution Cherenkov emission dosimetry and molecular sensing during clinical radio- therapy by imaging with SWIR wavelengths. (C) 2018 Optical Society of America

引用

页码：3854 / 3857

页数：4

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