Middle Ear "Adenoma": a Neuroendocrine Tumor with Predominant L Cell Differentiation

被引：20

作者：

Asa, Sylvia L. ^{[1
]}

Arkun, Knarik ^{[2
]}

Tischler, Arthur S. ^{[2
]}

Qamar, Adnan ^{[2
]}

Deng, Fang-Ming ^{[3
]}

Perez-Ordonez, Bayardo ^{[4
]}

Weinreb, Ilan ^{[4
]}

Bishop, Justin A. ^{[5
]}

Wenig, Bruce M. ^{[6
]}

Mete, Ozgur ^{[4
]}

机构：

[1] Case Western Reserve Univ, Univ Hosp Cleveland, Med Ctr, Dept Pathol, Cleveland, OH 44106 USA

[2] Tufts Med Ctr, Dept Pathol & Lab Med, Boston, MA USA

[3] NYU, Dept Pathol, Langone, NY USA

[4] Univ Toronto, Univ Hlth Network, Dept Pathol, Toronto, ON M5G 2C4, Canada

[5] Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX USA

[6] H Lee Moffitt Canc Ctr & Res Inst, Dept Pathol, Tampa, FL 33616 USA

来源：

ENDOCRINE PATHOLOGY | 2021年 / 32卷 / 04期

关键词：

Middle ear adenoma; Neuroendocrine tumor; L cell; GLICENTIN-IMMUNOREACTIVE CELLS; CARCINOID-TUMOR; PEPTIDE-YY; COEXISTENCE; FEATURES; GLUCAGON; LIGHT;

D O I：

10.1007/s12022-021-09684-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This morphological and immunohistochemical study demonstrates that tumors currently known as "middle ear adenomas" are truly well-differentiated epithelial neuroendocrine tumors (NETs) composed of cells comparable to normal intestinal L cells, and therefore, these tumors resemble hindgut NETs. These tumors show consistent expression of glucagon, pancreatic polypeptide, PYY, and the transcription factor SATB2, as well as generic neuroendocrine markers and keratins. The same L cell markers are expressed by cells within the normal middle ear epithelium. These markers define a valuable immunohistochemical profile that can be used for differential diagnosis of middle ear neoplasms, particularly in distinguishing epithelial NETs from paragangliomas. The discovery of neuroendocrine cells expressing the same markers in non-neoplastic middle ear mucosa opens new areas of investigation into the physiology of the normal middle ear and the pathophysiology of middle ear disorders.

引用

页码：433 / 441

页数：9

共 35 条

[1] 'Neuroendocrine' middle ear adenomas: consistent expression of the transcription factor ISL1 further supports their neuroendocrine derivation [J].

Agaimy, Abbas ;

Lell, Michael ;

Schaller, Tina ;

Maerkl, Bruno ;

Hornung, Joachim .

HISTOPATHOLOGY, 2015, 66 (02) :182-191

[2]

Angouridakis N, 2009, Rev Laryngol Otol Rhinol (Bord), V130, P199

[3]

[Anonymous], 2018, HISTOLOGY PATHOLOGIS

[4] The Diagnosis and Clinical Significance of Paragangliomas in Unusual Locations [J].

Asa, Sylvia L. ;

Ezzat, Shereen ;

Mete, Ozgur .

JOURNAL OF CLINICAL MEDICINE, 2018, 7 (09)

[5] MIDDLE-EAR ADENOMA - A CASE-REPORT WITH ULTRASTRUCTURAL FINDINGS [J].

BAILEY, QR ;

WEINER, JM .

JOURNAL OF LARYNGOLOGY AND OTOLOGY, 1986, 100 (04) :467-470

[6] Middle ear adenomatous neuroendocrine tumors: a 25-year experience at MD Anderson Cancer Center [J].

Bell, Diana ;

El-Naggar, Adel K. ;

Gidley, Paul W. .

VIRCHOWS ARCHIV, 2017, 471 (05) :667-672

[7] SATB2 in neuroendocrine neoplasms: strong expression is restricted to well-differentiated tumours of lower gastrointestinal tract origin and is most frequent in Merkel cell carcinoma among poorly differentiated carcinomas [J].

Bellizzi, Andrew M. .

HISTOPATHOLOGY, 2020, 76 (02) :251-264

[8]

BOTTCHER G, 1984, REGUL PEPTIDES, V8, P261, DOI 10.1016/0167-0115(84)90034-X

[9] COEXISTENCE OF GLICENTIN AND PEPTIDE-YY IN COLORECTAL L-CELLS IN CAT AND MAN - AN ELECTRON-MICROSCOPIC STUDY [J].

BOTTCHER, G ;

ALUMETS, J ;

HAKANSON, R ;

SUNDLER, F .

REGULATORY PEPTIDES, 1986, 13 (3-4) :283-291

[10]

COLONY PC, 1982, CELL TISSUE RES, V221, P483

← 1 2 3 4 →