Augmented Production of Panton-Valentine Leukocidin Toxin in Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Is Associated with Worse Outcome in a Murine Skin Infection Model

被引：34

作者：

Varshney, Avanish K. ^{[2
]}

Martinez, Luis R. ^{[2
]}

Hamilton, Stephanie M. ^{[4
]}

Bryant, Amy E. ^{[4
]}

Levi, Michael H. ^{[3
]}

Gialanella, Philip ^{[3
]}

Stevens, Dennis L. ^{[4
]}

Fries, Bettina C. ^{[1
,2
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Div Infect Dis, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[2] Yeshiva Univ Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[3] Montefiore Med Ctr, Microbiol Lab, Bronx, NY 10467 USA

[4] Ctr Vet Med, Boise, ID USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷 / 01期

关键词：

NECROTIZING PNEUMONIA; VIRULENCE DETERMINANT; STRAINS; LEUCOCIDIN; DISEASE; USA300; GENES;

D O I：

10.1086/648613

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus infections is controversial. We used a mouse model of skin infection to compare the virulence of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) strains with different levels of PVL production. Differences in PVL production were not associated with mutations in the genes lukS-PV and lukF-PV. However, MSSA and MRSA strains that produced high levels of PVL caused larger skin abscesses, higher bacterial burdens, and more tissue inflammation than did low-PVL-producing strains. Together, these data suggest that (1) the effect of PVL on the pathogenesis of staphylococcal infection may depend on the level of toxin produced and (2) many strains of MSSA that cause soft-tissue infections produce higher levels of PVL than do MRSA strains.

引用

页码：92 / 96

页数：5

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