Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells

被引：75

作者：

Hoeppner, Luke H. ^{[1
]}

Wang, Ying ^{[1
]}

Sharma, Anil ^{[1
]}

Javeed, Naureen ^{[1
]}

Van Keulen, Virginia P. ^{[2
]}

Wang, Enfeng ^{[1
]}

Yang, Ping ^{[3
,5
]}

Roden, Anja C. ^{[4
]}

Peikert, Tobias ^{[2
,3
]}

Molina, Julian R. ^{[4
,6
]}

Mukhopadhyay, Debabrata ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

[2] Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55905 USA

[3] Mayo Clin, Coll Med, Dept Med, Div Pulm & Crit Care Med, Rochester, MN 55905 USA

[4] Mayo Clin, Coll Med, Dept Lab Med & Pathol, Rochester, MN 55905 USA

[5] Mayo Clin, Coll Med, Dept Hlth Sci Res, Div Epidemiol, Rochester, MN 55905 USA

[6] Mayo Clin, Coll Med, Dept Med, Div Med Oncol, Rochester, MN 55905 USA

来源：

MOLECULAR ONCOLOGY | 2015年 / 9卷 / 01期

关键词：

Dopamine; Lung cancer; VEGF; Cabergoline; Angiogenesis; Dopamine D2 receptor agonists; ENDOTHELIAL GROWTH-FACTOR; QUALITY-OF-LIFE; CIGARETTE-SMOKING; POLYMORPHISMS; PHARMACOLOGY; VASCULATURE; CARBOPLATIN; PACLITAXEL; LETHALITY; DISEASE;

D O I：

10.1016/j.molonc.2014.08.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We sought to determine whether Dopamine D2 Receptor (D2R) agonists inhibit lung tumor progression and identify subpopulations of lung cancer patients that benefit most from D2R agonist therapy. We demonstrate D2R agonists abrogate lung tumor progression in syngeneic (LLC1) and human xenograft (A549) orthotopic murine models through inhibition of tumor angiogenesis and reduction of tumor infiltrating myeloid derived suppressor cells. Pathological examination of human lung cancer tissue revealed a positive correlation between endothelial D2R expression and tumor stage. Lung cancer patients with a smoking history exhibited greater levels of D2R in lung endothelium. Our results suggest D2R agonists may represent a promising individualized therapy for lung cancer patients with high levels of endothelial D2R expression and a smoking history. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：270 / 281

页数：12

共 52 条

[1] The 2014 Surgeon Generals Report: Commemorating the 50th Anniversary of the 1964 Report of the Advisory Committee to the US Surgeon General and Updating the Evidence on the Health Consequences of Cigarette Smoking [J].

Alberg, Anthony J. ;

Shopland, Donald R. ;

Cummings, K. Michael .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2014, 179 (04) :403-412

[2] Ablation of peripheral dopaminergic nerves stimulates malignant tumor growth by inducing vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis [J].

Basu, S ;

Sarkar, C ;

Chakroborty, D ;

Nagy, J ;

Mitra, RB ;

Dasgupta, PS ;

Mukhopadhyay, D .

CANCER RESEARCH, 2004, 64 (16) :5551-5555

[3] The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor [J].

Basu, S ;

Nagy, JA ;

Pal, S ;

Vasile, E ;

Eckelhoefer, IA ;

Bliss, VS ;

Manseau, EJ ;

Dasgupta, PS ;

Dvorak, HF ;

Mukhopadhyay, D .

NATURE MEDICINE, 2001, 7 (05) :569-574

[4] Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics [J].

Benowitz, Neal L. .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2009, 49 :57-71

[5] Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice [J].

Bhandarkar, Sulochana S. ;

Jaconi, Marisa ;

Fried, Levi E. ;

Bonner, Michael Y. ;

Lefkove, Benjamin ;

Govindarajan, Baskaran ;

Perry, Betsy N. ;

Parhar, Ravi ;

Mackelfresh, Jamie ;

Sohn, Allie ;

Stouffs, Michael ;

Knaus, Ulla ;

Yancopoulos, George ;

Reiss, Yvonne ;

Benest, Andrew V. ;

Augustin, Hellmut G. ;

Arbiser, Jack L. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (08) :2359-2365

[6]

Bhattacharya Resham, 2008, J Mol Signal, V3, P14, DOI 10.1186/1750-2187-3-14

[7]

Burns David M, 2003, Semin Oncol Nurs, V19, P244, DOI 10.1053/j.soncn.2003.08.001

[8] Polymorphisms of dopamine receptor/transporter genes and risk of non-small cell lung cancer [J].

Campa, Daniele ;

Zienolddiny, Shanbeh ;

Lind, Helge ;

Ryberg, David ;

Skaug, Vidar ;

Canzian, Federico ;

Haugen, Aage .

LUNG CANCER, 2007, 56 (01) :17-23

[9] Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele [J].

Carmeliet, P ;

Ferreira, V ;

Breier, G ;

Pollefeyt, S ;

Kieckens, L ;

Gertsenstein, M ;

Fahrig, M ;

Vandenhoeck, A ;

Harpal, K ;

Eberhardt, C ;

Declercq, C ;

Pawling, J ;

Moons, L ;

Collen, D ;

Risau, W ;

Nagy, A .

NATURE, 1996, 380 (6573) :435-439

[10]

Cetin Karynsa, 2011, Clin Epidemiol, V3, P139, DOI 10.2147/CLEP.S17191

← 1 2 3 4 5 6 →