Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-1-yl)quinolone derivatives

被引：15
|
作者：
Wang, Ju Xian
Guo, Qiang
Chai, Yun
Feng, Lian Shun
Guo, Hui Yuan
Liu, Ming Liang [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 01期
关键词：
Fluoroquinolone; Synthesis; Antibacterial activities; QUINOLONES;
D O I：
10.1016/j.cclet.2009.07.011
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of novel 7-(4-alkoxyimino-3-hydroxypiperidin-1-yl)quinolone derivatives were designed, synthesized and evaluated for in vitro antibacterial activities. Compounds 8f, 8g, 8i and 8j with the potencies similar to or better than those of levofloxacin and IMB against Staphylococcus aureus and Staphylococcus epidermidis, worth further investigation. (C) 2009 Ming Liang Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：55 / 58
页数：4
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