Effect of experimental diabetes on monoamine oxidase activity from discrete areas of rat brain: Relationship with diabetes associated reproductive failure

被引：12

作者：

Lakhman, SS ^{[1
]}

Kaur, G ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Biotechnol, Neurochem & Neuroendocrinol Lab, Amritsar 143005, Punjab, India

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1997年 / 177卷 / 1-2期

关键词：

diabetes; monoamine oxidase; reproductive failure; monoamines; brain; insulin; neuroendocrine regulation; gonadotropins;

D O I：

10.1023/A:1006851426257

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The effect of alloxan-induced diabetes was studied on the activity of monoamine oxidase (MAO), the oxidative deaminating enzyme of monoamine neurotransmitters. MAO wa's assayed from discrete brain regions like medial preoptic area and median eminence - arcuate region of hypothalamus, septum, amygdala, thalamus, hippocampus, pens and medulla. In all these areas studied, the induction of diabetes resulted in significant increase in MAO activity at 3, 8, 15 and 28 day intervals, whereas, the treatment of diabetic rats with insulin led to recovery in the enzyme activity. Blood glucose levels increased significantly after induction of diabetes and the recovery was seen after insulin treatment. These data suggest the involvement of MAO in diabetes associated alterations in physiological and endocrinological disorders.

引用

页码：15 / 20

页数：6

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