Bifonazole-β-cyclodextrin inclusion complexes.: Thermal analysis and X-ray powder diffraction study

The complexation of bifonazole, an antimycotic hydrophobic imidazole derivative, with beta -cyclodextrin (beta -CD) was investigated in solid phase, using the following complementary techniques: differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray powder diffractometry. The beta -CD-bifonazole samples were prepared in both aqueous medium by coprecipitation and in solid state by kneading method and the beta -CD-bifonazole binary diagrams were drawn. The experimental results demonstrate the formation of two binary compounds, beta -CD-bifonazole and (beta -CD)(x)bifonazole (x=2 or 4). The first compound may be an inclusion compound and the second a crystallized compound, in which the bifonazole is not necessarily included in the cyclodextrin internal cavity.