Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord

被引：14

作者：

Ritfeld, Gaby J. ^{[1
,5
]}

Tewarie, Rishi D. Nandoe ^{[6
]}

Rahiem, Sahar T. ^{[3
]}

Hurtado, Andres ^{[3
,4
]}

Roos, Raymund A. ^{[5
]}

Grotenhuis, Andre ^{[6
]}

Oudega, Martin ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Phys Med & Rehabil, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15213 USA

[3] Johns Hopkins Univ, Sch Med, Kennedy Krieger Inst, Int Ctr Spinal Cord Injury, Baltimore, MD USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[5] Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Neurosurg, NL-6525 ED Nijmegen, Netherlands

来源：

NEUROREPORT | 2010年 / 21卷 / 03期

关键词：

bone marrow stromal cell; cell survival; cell transplantation; macrophages; spinal cord injury; trauma; MESENCHYMAL STEM-CELLS; PARAPLEGIC RATS; CYCLOSPORINE-A; INJURY; RECOVERY; APOPTOSIS; GROWTH; DEATH;

D O I：

10.1097/WNR.0b013e32833677cd

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We tested whether reducing macrophage infiltration would improve the survival of allogeneic bone marrow stromal cells (BMSC) transplanted in the contused adult rat thoracic spinal cord. Treatment with cyclosporine, minocycline, or methylprednisolone all resulted in a significant decrease in macrophage infiltration at 3 days postinjury. However, when BMSC were injected at that time point survival 7 days later was similar between treatment groups and saline-injected controls. In fact we found that the presence of BMSC resulted in a significant increase in macrophage infiltration into the contusion. NeuroReport 21:221-226 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：221 / 226

页数：6

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