Progress and Controversies: Radiation Therapy for Prostate Cancer

Radiation therapy remains a standard treatment option for men with localized prostate cancer. Alone or in combination with androgen-deprivation therapy, it represents a curative treatment and has been shown to prolong survival in selected populations. In this article, the authors review recent advances in prostate radiationtreatment techniques, photon versus proton radiation, modification of treatment fractionation, and brachytherapyall focusing on disease control and the impact on morbidity. Also discussed are refinements in the risk stratification of men with prostate cancer and how these are better for matching patients to appropriate treatment, particularly around combined androgen-deprivation therapy. Many of these advances have cost and treatment burden implications, which have significant repercussions given the prevalence of prostate cancer. The discussion includes approaches to improve value and future directions for research. CA Cancer J Clin 2014;64:389-407. (c) 2014 American Cancer Society.