Translational biology of osteosarcoma

被引：1017
作者：
Kansara, Maya [1 ,2 ]
Teng, Michele W. [3 ,4 ,5 ]
Smyth, Mark J. [3 ,4 ,5 ]
Thomas, David M. [1 ,2 ,6 ]
机构：
[1] Peter MacCallum Canc Ctr, Div Res, Melbourne, Vic 3002, Australia
[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia
[3] OIMR Berghofer Med Res Inst, Immunol Canc & Infect Lab, Brisbane, Qld 4006, Australia
[4] OIMR Berghofer Med Res Inst, Canc Immunoregulat & Immunotherapy Lab, Brisbane, Qld 4006, Australia
[5] Univ Queensland, Sch Med, Herston, Qld 4006, Australia
[6] St Vincents Hosp, Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia
来源：
NATURE REVIEWS CANCER | 2014年 / 14卷 / 11期
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
HIGH-GRADE OSTEOSARCOMA; CHILDRENS ONCOLOGY GROUP; RAPAMYCIN INHIBITOR RIDAFOROLIMUS; COMPARATIVE GENOMIC HYBRIDIZATION; PRECLINICAL TESTING PROGRAM; ROTHMUND-THOMSON-SYNDROME; COLONY-STIMULATING FACTOR; TUMOR-REJECTION ANTIGEN; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR-I;
D O I：
10.1038/nrc3838
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
For the past 30 years, improvements in the survival of patients with osteosarcoma have been mostly incremental. Despite evidence of genomic instability and a high frequency of chromothripsis and kataegis, osteosarcomas carry few recurrent targetable mutations, and trials of targeted agents have been generally disappointing. Bone has a highly specialized immune environment and many immune signalling pathways are important in bone homeostasis. The success of the innate immune stimulant mifamurtide in the adjuvant treatment of non-metastatic osteosarconna suggests that newer immune-based treatments, such as immune checkpoint inhibitors, may substantially improve disease outcome.
引用
收藏
页码：722 / 735
页数：14
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