Translational biology of osteosarcoma

被引：1064

作者：

Kansara, Maya ^{[1
,2
]}

Teng, Michele W. ^{[3
,4
,5
]}

Smyth, Mark J. ^{[3
,4
,5
]}

Thomas, David M. ^{[1
,2
,6
]}

机构：

[1] Peter MacCallum Canc Ctr, Div Res, Melbourne, Vic 3002, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia

[3] OIMR Berghofer Med Res Inst, Immunol Canc & Infect Lab, Brisbane, Qld 4006, Australia

[4] OIMR Berghofer Med Res Inst, Canc Immunoregulat & Immunotherapy Lab, Brisbane, Qld 4006, Australia

[5] Univ Queensland, Sch Med, Herston, Qld 4006, Australia

[6] St Vincents Hosp, Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 11期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

HIGH-GRADE OSTEOSARCOMA; CHILDRENS ONCOLOGY GROUP; RAPAMYCIN INHIBITOR RIDAFOROLIMUS; COMPARATIVE GENOMIC HYBRIDIZATION; PRECLINICAL TESTING PROGRAM; ROTHMUND-THOMSON-SYNDROME; COLONY-STIMULATING FACTOR; TUMOR-REJECTION ANTIGEN; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR-I;

D O I：

10.1038/nrc3838

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

For the past 30 years, improvements in the survival of patients with osteosarcoma have been mostly incremental. Despite evidence of genomic instability and a high frequency of chromothripsis and kataegis, osteosarcomas carry few recurrent targetable mutations, and trials of targeted agents have been generally disappointing. Bone has a highly specialized immune environment and many immune signalling pathways are important in bone homeostasis. The success of the innate immune stimulant mifamurtide in the adjuvant treatment of non-metastatic osteosarconna suggests that newer immune-based treatments, such as immune checkpoint inhibitors, may substantially improve disease outcome.

引用

页码：722 / 735

页数：14

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