Increased Copy Number of the Gene Encoding SF3B4 Indicates Poor Prognosis in Hepatocellular Carcinoma

被引：1

作者：

Iguchi, Tomohiro ^{[1
]}

Komatsu, Hisateru ^{[1
]}

Masuda, Takaaki ^{[1
]}

Nambara, Sho ^{[1
]}

Kidogami, Shinya ^{[1
]}

Ogawa, Yushi ^{[1
]}

Hu, Qingjiang ^{[1
]}

Saito, Tomoko ^{[1
]}

Hirata, Hidenari ^{[1
]}

Sakimura, Shotaro ^{[1
]}

Uchi, Ryutaro ^{[1
]}

Hayashi, Naoki ^{[1
]}

Ito, Shuhei ^{[1
]}

Eguchi, Hidetoshi ^{[1
]}

Sugimachi, Keishi ^{[1
]}

Maehara, Yoshihiko ^{[2
]}

Mimori, Koshi ^{[1
]}

机构：

[1] Kyushu Univ, Beppu Hosp, Dept Surg, 4546 Tsurumihara, Beppu, Oita 8740838, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka 812, Japan

来源：

ANTICANCER RESEARCH | 2016年 / 36卷 / 05期

关键词：

SF3B; copy number alteration; hepatocellular carcinoma; progression; prognosis; SF2/ASF; PATHWAY; CANCER;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Defects in alternative splicing contribute to carcinogenesis, cancer progression and chemoresistance. The spliceosome pathway, including SF3B4, a component of spliceosomal complex is suggested to play a role in progression of hepatocellular carcinoma (HCC); however, the clinical relevance of SF3B4 in HCC remains unknown. Patients and Methods: SF3B4 expression was evaluated by real-time reverse transcription polymerase chain reaction in 72 HCC samples and non-cancerous liver samples. The relationship between the DNA copy number and SF3B4 expression levels was investigated using TCGA datasets. Results: SF3B4 expression was significantly higher in cancerous than in non-cancerous tissues and positively correlated with SF3B4 DNA copy number. High SF3B4 expression is significantly associated with intrahepatic metastasis and poor prognosis. These results were consistent with data from the public datasets. Conclusion: Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC.

引用

页码：2139 / 2144

页数：6

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