Beclin 1 mRNA strongly correlates with Bcl-XL mRNA expression in human hepatocellular carcinoma

被引：22

作者：

Daniel, F.

Legrand, A.

Pessayre, D.

Borrega-Pires, F.

Mbida, L.

Lardeux, B.

Degott, C.

van Nhieu, J. Tran

Bernuau, D.

机构：

[1] Univ Paris 07, INSERM, Fac Med Xavier Bichat, U481, Paris, France

[2] INSERM, Fac Med, U539, Nantes, France

[3] Hop Beaujon, Serv Anat Cytol Pathol, Clichy, France

[4] Hop Henri Mondor, Dept Pathol, F-94010 Creteil, France

来源：

CANCER INVESTIGATION | 2007年 / 25卷 / 04期

关键词：

beclin; 1; Bcl-X-L; hepatocellular carcinoma; autophagy; apoptosis; tumor suppressor;

D O I：

10.1080/07357900701206323

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Beclin 1 physically associates with BCl-x(L) and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was less than 0.5 in 2 tumors and more than 2 in 1 tumor, and was positively correlated with the Bcl-X-L mRNA T/NT ratio (P < 0.001), but not with the proliferating cell nuclear antigen mRNA T/NT ratio. Coregulation of Beclin 1 and Bcl-XL expression in HCC may suggest cooperation in the regulation of apoptosis.

引用

页码：226 / 231

页数：6

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[11] Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival [J].