Beclin 1 mRNA strongly correlates with Bcl-XL mRNA expression in human hepatocellular carcinoma

被引：22
作者：
Daniel, F.
Legrand, A.
Pessayre, D.
Borrega-Pires, F.
Mbida, L.
Lardeux, B.
Degott, C.
van Nhieu, J. Tran
Bernuau, D.
机构：
[1] Univ Paris 07, INSERM, Fac Med Xavier Bichat, U481, Paris, France
[2] INSERM, Fac Med, U539, Nantes, France
[3] Hop Beaujon, Serv Anat Cytol Pathol, Clichy, France
[4] Hop Henri Mondor, Dept Pathol, F-94010 Creteil, France
来源：
CANCER INVESTIGATION | 2007年 / 25卷 / 04期
关键词：
beclin; 1; Bcl-X-L; hepatocellular carcinoma; autophagy; apoptosis; tumor suppressor;
D O I：
10.1080/07357900701206323
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Beclin 1 physically associates with BCl-x(L) and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was less than 0.5 in 2 tumors and more than 2 in 1 tumor, and was positively correlated with the Bcl-X-L mRNA T/NT ratio (P < 0.001), but not with the proliferating cell nuclear antigen mRNA T/NT ratio. Coregulation of Beclin 1 and Bcl-XL expression in HCC may suggest cooperation in the regulation of apoptosis.
引用
收藏
页码：226 / 231
页数：6
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