Digital transformation provides companies with a productive approach to transforming and upgrading enterprise resources and capabilities and to exploiting external subject forces to unleash and magnify their potential, thus advancing high -quality enterprise development. Therefore, using regression analysis of the data of China's non -financial listed firms from 2007-2019 obtained by Python, this paper finds that digital transformation has enormously improved enterprise performance. Furthermore, digital transformation has powerfully boosted supply chain integration, which has played a mediation role in the impact of digital transformation on enterprise performance. Finally, entrepreneurship plays a positive moderating effect on enterprise performance through supply chain integration during digital transformation. The further heterogeneity analysis finds that digital transformation performs better in large, public, state-owned, mature, and non -manufacturing (service industry) enterprises. However, the positive effect of digital transformation on enterprise performance and supply chain integration is not significant in small and medium-sized enterprises. Therefore, supply chain integration cannot play a mediating role in the impact of digital transformation of manufacturing enterprises upon their performance. This paper probes the realization mechanism and micro -foundation of digital transformation, and its conclusion contributes to high -quality digital transformation.