CHEMOSELECTIVE OXIDATION OF OLEANOLIC ACID DERIVATIVES WITH OZONE

被引：11

作者：

Kazakova, O. B. ^{[1
]}

Medvedeva, N. I. ^{[1
]}

Kukovinets, O. S. ^{[1
]}

Tolstikov, G. A. ^{[1
]}

Khusnutdinova, E. F. ^{[1
]}

Zaprutko, L. ^{[2
]}

Bednarczyk-Cwynar, B. ^{[2
]}

Paryzek, Z. ^{[3
]}

机构：

[1] Russian Acad Sci, Inst Organ Chem, Ufa Sci Ctr, Ufa 450054, Russia

[2] Poznan Univ Med Sci, Fac Pharm, Chair & Dept Organ Chem, Poznan, Poland

[3] Adam Mickiewicz Univ, Fac Chem, Dept Bioorgan Chem, Poznan, Poland

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2010年 / 46卷 / 03期

关键词：

oleanolic acid; chemoselectivity; oxidation; ozonolysis; TRITERPENOIDS; INHIBITION; MECHANISM;

D O I：

10.1007/s10600-010-9627-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method for preparing methyl esters of 12-oxoolean-28-oic and 3,12-dioxoolean-28-oic acids via ozonolysis of oleanolic acid methyl ester in CH2Cl2 at -60 degrees C was proposed. It was found that oxidation of 2-cyano-3,4-seco-4(23)-oleanenoic acid was chemoselective depending on the amount of ozone used.

引用

页码：397 / 399

页数：3

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