Extracellular vesicles and their diagnostic potential in amyotrophic lateral sclerosis

被引：11
作者：
Roy, Jeremy [1 ]
Saucier, Daniel [2 ,3 ]
O'Connell, Colleen [4 ]
Morin, Pier, Jr. [5 ]
机构：
[1] Atlantic Canc Res Inst, Pavillon Hotel Dieu,35 Providence St, Moncton, NB E1C 8X3, Canada
[2] Univ Sherbrooke, Fac Med & Hlth Sci, 2500 Univ Blvd, Sherbrooke, PQ J1K 2R1, Canada
[3] Ctr Format Med Nouveau Brunswick, 100 Aboiteaux St, Moncton, NB E1A 7R1, Canada
[4] Stan Cassidy Ctr Rehabil, 800 Priestman St, Fredericton, NB E3B 0C7, Canada
[5] Univ Moncton, Dept Chem & Biochem, 18 Antonine Maillet Ave, Moncton, NB E1A 3E9, Canada
来源：
CLINICA CHIMICA ACTA | 2019年 / 497卷
关键词：
Extracellular vesicles; Exosomes; Diagnostic tool; Liquid biopsy; Neurodegenerative diseases; Amyotrophic lateral sclerosis; DIPEPTIDE-REPEAT PROTEINS; SUPEROXIDE-DISMUTASE GENE; PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; HEXANUCLEOTIDE REPEAT; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; PROTEOMIC ANALYSIS; EXOSOMES; ALS;
D O I：
10.1016/j.cca.2019.07.012
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Extracellular vesicles, small reservoirs that carry various biomolecules, have gained significant interest from the clinical field in recent years based on the diagnostic, therapeutic and prognostic possibilities they offer. While information abound regarding the clinical potential of such vesicles in diverse conditions, the information demonstrating their likely importance in amyotrophic lateral sclerosis (ALS) is more limited. This review will thus provide a brief introduction to extracellular vesicles, highlight their diagnostic significance in various diseases with a focus on ALS and explore additional applications of extracellular vesicles in the medical field. Overall, this work sheds further light on the clinical importance of extracellular vesicles in diagnostic applications as well as supports the need to better characterize their roles and signatures in patients diagnosed with ALS.
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收藏
页码：27 / 34
页数：8
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