Sensitive Naked Eye Detection of Hydrogen Sulfide and Nitric Oxide by Aza-BODIPY Dyes in Aqueous Medium

被引:99
作者
Adarsh, Nagappanpillai [1 ]
Krishnan, Megha S. [1 ]
Ramaiah, Danaboyina [1 ,2 ]
机构
[1] CSIR Natl Inst Interdisciplinary Sci & Technol CS, Chem Sci & Technol Div, Trivandrum 695019, Kerala, India
[2] CSIR NEIST, Jorhat 785006, Assam, India
关键词
SINGLET OXYGEN GENERATION; ENERGY-TRANSFER; SELECTIVE RECOGNITION; FLUORESCENT-PROBES; STRAND DNA; RELEASE; DERIVATIVES; BINDING; QUANTIFICATION; POLYMER;
D O I
10.1021/ac502849d
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
With an objective to develop optical probes for biologically important anions and neutral molecules, we synthesized three novel NIR absorbing aza-BODIPY derivatives, 3a-3c, and have systematically tuned their photophysical properties by changing the peripheral substitution. A profound red-shift was observed in the absorption and fluorescence spectra of the aza-BODIPY dyes with the change in substitution from azido (3a) to amino (3b) to dimethylamino (3c) groups. Theoretical calculations of 3a-3c showed a consistent decrease in bandgap, which supports the observed spectral changes. The study of their interactions with various analytes revealed that the azido-aza-BODIPY 3a selectively interacts with hydrogen sulfide (H2S) when compared to other molecules. Uniquely, the detection of H2S can be visualized through a change in color from bright blue to purple with a detection limit of 0.5 ppm. The sensitivity of the probe was observed to be similar to 20-fold higher than the allowed exposure limits of H2S as defined by EPA (10 ppm). The aza-BODIPY derivative 3b, on the other hand, exhibited selective interactions with nitrite ions (NO2) and nitric oxide (NO) in aqueous medium through a visible color change from blue to green with a sensitivity of 20 and 0.15 ppb, respectively. In contrast, the dimethylamino-aza-BODIPY derivative, 3c, showed negligible affinity for the anions and neutral molecules tested. By tuning the photophysical properties through the judicious functionalization, the aza-BODIPY dyes thus synthesized can be utilized for the sensitive on-site detection and analysis of H2S, NO2-, and NO in the aqueous medium.
引用
收藏
页码:9335 / 9342
页数:8
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