Screening of New Caledonian and Vanuatu medicinal plants for antiprotozoal activity

被引：17

作者：

Billo, M

Fournet, A

Cabalion, P

Waikedre, J

Bories, C

Loiseau, P

Prina, E

de Arias, AR

Yaluff, G

Fourneau, C

Hocquemiller, R

机构：

[1] Univ Paris Sud, Fac Pharm, CNRS, BioCIS,Lab Pharmacognosie, F-92296 Chatenay Malabry, France

[2] US EnBioPac, IRD, SNT&ST, Noumea 98848, New Caledonia

[3] Univ Paris Sud, UMR 8076, CNRS, Fac Pharm, F-92296 Chatenay Malabry, France

[4] Inst Pasteur, Unite Immunophysiol & Parasitisme Intracellulaire, F-75724 Paris 15, France

[5] Univ Nacl Asuncion, Inst Invest Ciencias Salud, Dept Trop Med, Asuncion 2511, Paraguay

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 96卷 / 03期

关键词：

New Caledonia; Vanuatu; leishmanicidal activity; trypanocidal activity;

D O I：

10.1016/j.jep.2004.10.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sixty-seven extracts of 30 medicinal plants traditionally used in New Caledonia or Vanuatu by healers to treat inflammation, fever and in cicatrizing remedies were evaluated in vitro for their antiprotozoal activity against Leishmania donovani, Leishmania amazonensis and Trypanosoma cruzi. Among the selected plants, Pagiantha cerifera was the most active against both Leishmania species; four extracts were active against promastigotes of Leishmania donovani at EC50 values inferior to 5 mug/ml. Garcinia pedicillata extract had an EC50 value of 12.5 mug/ml against intracellular amastigotes of Leishmania amazonensis. Alone Amborella trichopoda reduced by more of 80% the trypomastigotes of Trypanosoma cruzi in the blood. (C) 2004 Published by Elsevier Ireland Ltd.

引用

页码：569 / 575

页数：7

共 14 条

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