Synthesis of a new series of pyrazolo[1,5-a]pyrimidines structurally related to zaleplon

被引：24

作者：

Baraldi, Pier Giovanni ^{[1
]}

Fruttarolo, Francesca

Tabrizi, Mojgan Aghazadeh

Romagnoli, Romeo

Preti, Delia

Ongini, Ennio

El-Kashef, Hussein

Dora Carrion, Maria

Borea, Pier Andrea

机构：

[1] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy

[2] Univ Ferrara, Dipartimento Med Clin & Sperimentale, Sez Farmacol, I-44100 Ferrara, Italy

[3] Univ Granada, Dept Quim Farmaceut & Organ, Granada 18071, Spain

[4] NicOx Res Inst, I-20091 Milan, Italy

[5] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 02期

关键词：

D O I：

10.1002/jhet.5570440212

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction between 3-(dimethylamino)/3,3-bis(methylthio)-1-(substituted)prop-2-en-1-ones and 4-substituted-5-amino-1H-pyrazoles afforded new pyrazole[1,5-a]pyrimidines structurally related to Zaleplon. The chemical modifications introduced at the 3-, 5-, and 7-positions of the bicyclic structure revealed new promising candidates for the treatment of sleep disorders.

引用

页码：355 / 361

页数：7

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