Pathophysiology and immunogenetics of celiac disease

被引:20
作者
Aboulaghras, Sara [1 ,3 ]
Piancatelli, Daniela [2 ]
Oumhani, Khadija [3 ]
Balahbib, Abdelaali [4 ]
Bouyahya, Abdelhakim [5 ]
Taghzouti, Khalid [1 ]
机构
[1] Mohammed V Univ Rabat, Fac Sci Genom Human Pathol Res, Genom Human Pathol Res, Physiol & Physiopathol Team, Rabat, Morocco
[2] Natl Res Council CNR, Inst Translat Pharmacol IFT, Laquila, Italy
[3] Inst Natl Hyg, Lab Immunol, Rabat, Morocco
[4] Mohammed V Univ Rabat, Fac Sci, Lab Zool & Gen Biol, Rabat, Morocco
[5] Mohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol Res, Dept Biol,Lab Human Pathol Biol, Rabat, Morocco
关键词
Celiac disease; HLA; Physiopathology; Transglutaminase; 2; Microbiota; RESTRICTED T-CELLS; GLUTEN-FREE DIET; TISSUE TRANSGLUTAMINASE; HLA-DQ; INTERFERON-GAMMA; GUT MICROBIOTA; INTESTINAL PERMEABILITY; STORAGE PROTEINS; GLIADIN; PREVALENCE;
D O I
10.1016/j.cca.2022.01.022
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Celiac disease (CD) is a chronic inflammatory enteropathy caused by gluten (protein from wheat, rye and, barley) in genetically predisposed individuals carrying the HLA-DQ2/HLA-DQ8 genotype. This pathology has a multi factorial etiology in which HLA genes, the microbiome, gluten and, other environmental factors are involved in the development of the disease. Its pathogenesis involves both innate and adaptive immunity as well as upregulation of IL-15. The objective of this review is to examine the results of current studies on genetic and environmental variables to better understand the pathogenesis of this enteropathy. The complex etiology of celiac disease makes our understanding of the pathogenesis of the disease incomplete, and a better knowledge of the many genetic and environmental components would help us better understand the pathophysiology of celiac disease.
引用
收藏
页码:74 / 83
页数:10
相关论文
共 148 条
[71]   Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3 [J].
Lammers, Karen M. ;
Lu, Ruliang ;
Brownley, Julie ;
Lu, Bao ;
Gerard, Craig ;
Thomas, Karen ;
Rallabhandi, Prasad ;
Shea-Donohue, Terez ;
Tamiz, Amir ;
Alkan, Sefik ;
Netzel-Arnett, Sarah ;
Antalis, Toni ;
Vogel, Stefanie N. ;
Fasano, Alessio .
GASTROENTEROLOGY, 2008, 135 (01) :194-204
[72]   B Lymphocytes Contribute to Celiac Disease Pathogenesis [J].
Lejeune, Thomas ;
Meyer, Celine ;
Abadie, Valerie .
GASTROENTEROLOGY, 2021, 160 (07) :2608-+
[73]   Coeliac disease [J].
Lindfors, Katri ;
Ciacci, Carolina ;
Kurppa, Kalle ;
Lundin, Knut E. A. ;
Makharia, Govind K. ;
Mearin, M. Luisa ;
Murray, Joseph A. ;
Verdu, Elena F. ;
Kaukinen, Katri .
NATURE REVIEWS DISEASE PRIMERS, 2019, 5 (1)
[74]   T-CELL ACTIVATION CAN INDUCE EITHER MUCOSAL DESTRUCTION OR ADAPTATION IN CULTURED HUMAN FETAL SMALL-INTESTINE [J].
LIONETTI, P ;
BREESE, E ;
BRAEGGER, CP ;
MURCH, SH ;
TAYLOR, J ;
MACDONALD, TT .
GASTROENTEROLOGY, 1993, 105 (02) :373-381
[75]   Risk of Pediatric Celiac Disease According to HLA Haplotype and Country [J].
Liu, Edwin ;
Lee, Hye-Seung ;
Aronsson, Carin A. ;
Hagopian, William A. ;
Koletzko, Sibylle ;
Rewers, Marian J. ;
Eisenbarth, George S. ;
Bingley, Polly J. ;
Bonifacio, Ezio ;
Simell, Ville ;
Agardh, Daniel .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (01) :42-49
[76]   Decrease in lactobacilli in the intestinal microbiota of celiac children with a gluten-free diet, and selection of potentially probiotic strains [J].
Lorenzo Pisarello, Maria J. ;
Vintini, Elisa O. ;
Gonzalez, Silvia N. ;
Pagani, Florencia ;
Medina, Marcela S. .
CANADIAN JOURNAL OF MICROBIOLOGY, 2015, 61 (01) :32-37
[77]   Interleukin-9 upregulates mucus expression in the airways [J].
Louahed, J ;
Toda, M ;
Jen, J ;
Hamid, Q ;
Renauld, JC ;
Levitt, RC ;
Nicolaides, NC .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2000, 22 (06) :649-656
[78]   Estimation of the celiac disease prevalence in Denmark and the diagnostic value of HLA-DQ2/DQ8 [J].
Lund, Flemming ;
Pedersen, Merete Frejstrup ;
Kristiansen, Soren .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2020, 80 (08) :667-671
[79]   GLIADIN-SPECIFIC, HLA-DQ(ALPHA-1-ASTERISK-0501,BETA-1-ASTERISK-0201) RESTRICTED T-CELLS ISOLATED FROM THE SMALL-INTESTINAL MUCOSA OF CELIAC-DISEASE PATIENTS [J].
LUNDIN, KEA ;
SCOTT, H ;
HANSEN, T ;
PAULSEN, G ;
HALSTENSEN, TS ;
FAUSA, O ;
THORSBY, E ;
SOLLID, LM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (01) :187-196
[80]   Tissue transglutaminase as the autoantigen of coeliac disease [J].
Maki, M .
GUT, 1997, 41 (04) :565-566