Targeting epithelial-mesenchymal transition: Metal organic network nano-complexes for preventing tumor metastasis

被引：64

作者：

Fan, Jin-Xuan ^{[1
]}

Zheng, Di-Wei ^{[1
,2
]}

Rong, Lei ^{[1
]}

Zhu, Jing-Yi ^{[1
]}

Hong, Sheng ^{[1
]}

Li, Cao ^{[2
]}

Xu, Zu-Shun ^{[2
]}

Cheng, Si-Xue ^{[1
]}

Zhang, Xian-Zheng ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Key Lab Biomed Polymers, Minist Educ,IAS, Wuhan 430072, Peoples R China

[2] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Key Lab Green Preparat & Applicat Funct Mat, Minist Educ, Wuhan 430062, Hubei, Peoples R China

来源：

BIOMATERIALS | 2017年 / 139卷

基金：

中国国家自然科学基金;

关键词：

Epithelial-mesenchymal transition; Tumor metastasis; Multidrug resistance; Nano-medicine; Anti-cancer therapy; ENHANCED PHOTODYNAMIC THERAPY; DRUG-DELIVERY; MULTIDRUG-RESISTANCE; LUNG METASTASIS; BREAST-CANCER; NANOPARTICLES; MICROENVIRONMENT; CHEMORESISTANCE; PROGRESSION; RELEASE;

D O I：

10.1016/j.biomaterials.2017.06.007

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Tumor metastasis is the leading cause of death in cancer patients, and epithelial-mesenchymal transition (EMT) is an essential step in tumor metastasis. Unfortunately, during the chemotherapy, EMT could be induced under the selective pressure of clinical cytotoxic drugs. Here, to solve this problem, we have synthesized multi-functional epigallocatechin gallate/iron nano-complexes (EIN) as a versatile coating material to improve conventional therapies. In vitro studies showed that this strategy could eliminate EMT-type cancer cells. Mechanism studies also revealed that EIN was able to down-regulate the downstream expression of metastasis-associated factors, decrease the migration ability of cancer cells and prevent cancer cells from gaining drug resistance. In vivo investigation revealed that EIN had superior ability to enhance the therapeutic effect of conventional nanomedicines and inhibit the EMT process. Our study indicates the promising use of EIN to make up for the deficiencies of chemotherapy may provide insights into systematic cancer therapy to overcome tumor metastasis and drug resistance. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：116 / 126

页数：11

共 35 条

[1] Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].

Aceto, Nicola ;

Bardia, Aditya ;

Miyamoto, David T. ;

Donaldson, Maria C. ;

Wittner, Ben S. ;

Spencer, Joel A. ;

Yu, Min ;

Pely, Adam ;

Engstrom, Amanda ;

Zhu, Huili ;

Brannigan, Brian W. ;

Kapur, Ravi ;

Stott, Shannon L. ;

Shioda, Toshi ;

Ramaswamy, Sridhar ;

Ting, David T. ;

Lin, Charles P. ;

Toner, Mehmet ;

Haber, Daniel A. ;

Maheswaran, Shyamala .

CELL, 2014, 158 (05) :1110-1122

[2] Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nano carriers [J].

Cabral, Horacio ;

Makino, Jun ;

Matsumoto, Yu ;

Mi, Peng ;

Wu, Hailiang ;

Nomoto, Takahiro ;

Toh, Kazuko ;

Yamada, Naoki ;

Higuchi, Yuriko ;

Konishi, Satoshi ;

Kano, Mitsunobu R. ;

Nishihara, Hiroshi ;

Miura, Yutaka ;

Nishiyama, Nobuhiro ;

Kataoka, Kazunori .

ACS NANO, 2015, 9 (05) :4957-4967

[3] Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer [J].

Cao, Haiqiang ;

Dan, Zhaoling ;

He, Xinyu ;

Zhang, Zhiwen ;

Yu, Haijun ;

Yin, Qi ;

Li, Yaping .

ACS NANO, 2016, 10 (08) :7738-7748

[4]

Chung JE, 2014, NAT NANOTECHNOL, V9, P907, DOI [10.1038/NNANO.2014.208, 10.1038/nnano.2014.208]

[5] Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features [J].

Creighton, Chad J. ;

Li, Xiaoxian ;

Landis, Melissa ;

Dixon, J. Michael ;

Neumeister, Veronique M. ;

Sjolund, Ashley ;

Rimm, David L. ;

Wong, Helen ;

Rodriguez, Angel ;

Herschkowitz, Jason I. ;

Fan, Cheng ;

Zhang, Xiaomei ;

He, Xiaping ;

Pavlick, Anne ;

Gutierrez, M. Carolina ;

Renshaw, Lorna ;

Larionov, Alexey A. ;

Faratian, Dana ;

Hilsenbeck, Susan G. ;

Perou, Charles M. ;

Lewis, Michael T. ;

Rosen, Jeffrey M. ;

Chang, Jenny C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (33) :13820-13825

[6] New functions for the matrix metalloproteinases in cancer progression [J].

Egeblad, M ;

Werb, Z .

NATURE REVIEWS CANCER, 2002, 2 (03) :161-174

[7] One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering [J].

Ejima, Hirotaka ;

Richardson, Joseph J. ;

Liang, Kang ;

Best, James P. ;

van Koeverden, Martin P. ;

Such, Georgina K. ;

Cui, Jiwei ;

Caruso, Frank .

SCIENCE, 2013, 341 (6142) :154-157

[8] A Smart Photosensitizer-Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells [J].

Fan, Huanhuan ;

Yan, Guobei ;

Zhao, Zilong ;

Hu, Xiaoxiao ;

Zhang, Wenhan ;

Liu, Hui ;

Fu, Xiaoyi ;

Fu, Ting ;

Zhang, Xiao-Bing ;

Tan, Weihong .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (18) :5477-5482

[9] Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance [J].

Fischer, Kari R. ;

Durrans, Anna ;

Lee, Sharrell ;

Sheng, Jianting ;

Li, Fuhai ;

Wong, Stephen T. C. ;

Choi, Hyejin ;

El Rayes, Tina ;

Ryu, Seongho ;

Troeger, Juliane ;

Schwabe, Robert F. ;

Vahdat, Linda T. ;

Altorki, Nasser K. ;

Mittal, Vivek ;

Gao, Dingcheng .

NATURE, 2015, 527 (7579) :472-+

[10] ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma [J].

Frank, NY ;

Margaryan, A ;

Huang, Y ;

Schatton, T ;

Waaga-Gasser, AM ;

Gasser, M ;

Sayegh, MH ;

Sadee, W ;

Frank, MH .

CANCER RESEARCH, 2005, 65 (10) :4320-4333

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