Taurine-modified Ru(II)-complex targets cancerous brain cells for photodynamic therapy

被引：35
作者：
Du, Enming [1 ]
Hu, Xunwu [1 ]
Roy, Sona [1 ]
Wang, Peng [2 ]
Deasy, Kieran [3 ]
Mochizuki, Toshiaki [4 ]
Zhang, Ye [1 ]
机构：
[1] Okinawa Inst Sci & Technol, Bioinspired Soft Matter Unit, 1919-1 Tancha, Onna Son, Okinawa 9040495, Japan
[2] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China
[3] Okinawa Inst Sci & Technol, Mech Engn & Microfabricat Support Sect, 1919-1 Tancha, Onna Son, Okinawa 9040495, Japan
[4] Okinawa Inst Sci & Technol, Imaging Sect, 1919-1 Tancha, Onna Son, Okinawa 9040495, Japan
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 44期
关键词：
RUTHENIUM(II) POLYPYRIDYL COMPLEXES; CENTRAL-NERVOUS-SYSTEM; PHOTOSENSITIZERS; HOMEOSTASIS; OXYGEN; TUMORS; ACID;
D O I：
10.1039/c7cc03337k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The precision and efficacy of photodynamic therapy (PDT) is essential for the treatment of brain tumors because the cancer cells are within or adjacent to the delicate nervous system. Taurine is an abundant amino acid in the brain that serves the central nervous system (CNS). A taurine-modified polypyridyl Ru-complex was shown to have optimized intracellular affinity in cancer cells through accumulation in lysosomes. Symmetrical modification of this Ru-complex by multiple taurine molecules enhanced the efficiency of molecular emission with boosted generation of reactive oxygen species. These characteristic features make the taurine-modified Ru-complex a potentially effective photosensitizer for PDT of target cancer cells, with outstanding efficacy in cancerous brain cells.
引用
收藏
页码：6033 / 6036
页数：4
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