T Cell Exhaustion: An Epigenetically Imprinted Phenotypic and Functional Makeover

被引：15

作者：

Alfei, Francesca ^{[1
]}

Zehn, Dietmar ^{[1
]}

机构：

[1] Tech Univ Munich, Div Anim Physiol & Immunol, Sch Life Sci Weihenstephan, D-85354 Freising Weihenstephan, Germany

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 09期

关键词：

ANTIGEN; INFECTION; DIFFERENTIATION; PD-1;

D O I：

10.1016/j.molmed.2017.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent article in Cell demonstrates that the absence of a single DNA methyltransferase, Dnmt3a, prevents cytotoxic T cells from acquiring the hypofunctional or exhausted phenotype typically seen in chronic viral infections and tumors. Upon establishing a causal relationship between exhaustion-associated epigenetic changes and reduced CD8(+) T cell function, the authors provided mechanistic evidence that exhaustion constitutes a specific differentiation program.

引用

页码：769 / 771

页数：3

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