Vanadium-catalyzed anti-selective additions of allenols to imines

被引：45

作者：

Trost, BM ^{[1
]}

Jonasson, C ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 18期

关键词：

allenols; asymmetric catalysis; atom economy; imines; sigmatropic rearrangement; vanadium;

D O I：

10.1002/anie.200350890

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An atom-economic route to versatile building blocks: Vanadium enolates, which were generated in situ by the [3,3] sigmatropic rearrangement of vanadyl esters of allenic alcohols, undergo facile addition to imines derived from aromatic aldehydes to yield bifunctional β′-aminoα,β-unsaturated enones [Eq. (1)]. With 1,3-disubstituted allenes, good anti selectivity is observed in most cases.

引用

页码：2063 / 2066

页数：4

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