Aromatic interaction of hydantoin compounds leads to virucidal activities

被引：6

作者：

Nishinami, Suguru ^{[1
]}

Ikeda, Keiko ^{[2
]}

Nagao, Tamiko ^{[3
]}

Koyama, A. Hajime ^{[4
]}

Arakawa, Tsutomu ^{[5
]}

Shiraki, Kentaro ^{[1
]}

机构：

[1] Univ Tsukuba, Fac Pure & Appl Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058573, Japan

[2] Wakayama Med Univ, Sch Hlth & Nursing Sci, 580 Mikazura, Wakayama 6410011, Japan

[3] Shikoku Univ Jr Coll, Dept Sci Human Hlth Welf Care Major, Tokushima 7711192, Japan

[4] Wakayama Med Univ, Grad Sch Med, 580 Mikazura, Wakayama 6410011, Japan

[5] Alliance Prot Labs, San Diego, CA 92130 USA

来源：

BIOPHYSICAL CHEMISTRY | 2021年 / 275卷

关键词：

Virus; Protein; Amino acids; Aromatic interaction; Hydantoin; VIRUS INACTIVATION; AMINO-ACIDS; ARGININE; PROTEIN; SOLVENT/DETERGENT;

D O I：

10.1016/j.bpc.2021.106621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Virus inactivation or disinfection is the first line of protection against virus infection. Here, we report for the first time the virus inactivation (virucidal) activities of hydantoin and its derivative, 1-methylhydantoin against enveloped herpes simplex virus type-1. These hydantoin compounds showed favorable interaction with aromatic amino acids, similarly to arginine hydrochloride also exhibiting aromatic interaction and virucidal activities on the same virus. Among them, 1-methylhydantoin demonstrated a greater virucidal activity. Solubility measurements in organic solvents and salting-out salt solutions showed that 1-methylhydantoin is more hydrophobic than others, suggesting that the hydrophobic nature and aromatic interaction play a role in interaction with viral proteins and thereby virucidal activity.

引用

页数：6

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