Long-Term Treatment with Shengmai San-Derived Herbal Supplement (Wei Kang Su) Enhances Antioxidant Response in Various Tissues of Rats with Protection Against Carbon Tetrachloride Hepatotoxicity

被引：9
作者：
Leong, Pou Kuan [1 ]
Chen, Na [1 ]
Chiu, Po Yee [1 ]
Leung, Hoi Yan [1 ]
Ma, Chung Wah [2 ]
Tang, Qing Tao [2 ]
Ko, Kam Ming [1 ]
机构：
[1] Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
[2] Lee Kum Kee Hlth Prod Grp Ltd, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF MEDICINAL FOOD | 2010年 / 13卷 / 02期
关键词：
carbon tetrachloride; glutathione; heat shock response; mitochondria; reactive oxygen metabolites; HEAT-SHOCK PROTEINS; SCHISANDRIN-B; OXIDATIVE STRESS; MAI-SAN; LIPID-PEROXIDATION; STRUCTURAL INTEGRITY; INDUCED CYTOTOXICITY; REDOX STATUS; AGED RATS; VITAMIN-E;
D O I：
10.1089/jmf.2009.1296
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Wei Kang Su (WKS) is a commercial herbal product based on a Chinese herbal formula, Shengmai San. Here, we investigated the effects of long-term treatment with WKS on mitochondrial antioxidant status and functional ability, as well as heat shock protein (Hsp) 25/70 production, in various tissues of rats. WKS treatment enhanced mitochondrial antioxidant status and ATP generation capacity, as well as Hsp 25/70 production in various rat tissues. WKS treatment suppressed plasma reactive oxygen metabolite levels and protected against carbon tetrachloride hepatotoxicity in rats. Long-term WKS treatment may prevent diseases by enhancing the resistance of mitochondria to oxidative stress.
引用
收藏
页码：427 / 438
页数：12
相关论文
共 53 条
  • [1] Hsp27: Novel regulator of intracellular redox state
    Arrigo, AP
    [J]. IUBMB LIFE, 2001, 52 (06) : 303 - 307
  • [2] Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels
    Arrigo, AP
    Virot, S
    Chaufour, S
    Firdaus, W
    Kretz-Remy, C
    Diaz-Latoud, C
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2005, 7 (3-4) : 414 - 424
  • [3] Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury
    Burcham, P. C.
    Kaminskas, L. M.
    Tan, D.
    Pyke, S. M.
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2008, 8 (04) : 319 - 330
  • [4] Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats
    Chen, Na
    Chiu, Po Yee
    Ko, Kam Ming
    [J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (07) : 1387 - 1391
  • [5] Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats
    Chiu, Po Yee
    Leung, Hoi Yan
    Ko, Kam Ming
    [J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (04) : 602 - 605
  • [6] Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats
    Chiu, Po Yee
    Leung, Hoi Yan
    Poon, Michel K. T.
    Ko, Kam Ming
    [J]. BIOGERONTOLOGY, 2006, 7 (04) : 199 - 210
  • [7] Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury
    Chiu, PY
    Ko, KM
    [J]. BIOFACTORS, 2003, 19 (1-2) : 43 - 51
  • [8] Hepatoprotective mechanism of schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins
    Chiu, PY
    Tang, MH
    Mak, DHF
    Poon, MKT
    Ko, KM
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2003, 35 (04) : 368 - 380
  • [9] *CTR DRUG EV RES F, 2005, EST MAX SAF START DO
  • [10] Ding Xiao-Fei, 2007, Zhongguo Zhong Yao Za Zhi, V32, P2298
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